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Literature summary extracted from

  • Raje, M.; Hin, N.; Duvall, B.; Ferraris, D.V.; Berry, J.F.; Thomas, A.G.; Alt, J.; Rojas, C.; Slusher, B.S.; Tsukamoto, T.
    Synthesis of kojic acid derivatives as secondary binding site probes of D-amino acid oxidase (2013), Bioorg. Med. Chem. Lett., 23, 3910-3913.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.3 2-(hydroxymethyl)-5-((4-methoxybenzyl)oxy)-4H-pyran-4-one
-
 Homo sapiens
1.4.3.3 2-[(3,4-dichlorophenoxy)methyl]-5-hydroxy-4H-pyran-4-one
-
 Homo sapiens
1.4.3.3 2-[(4-chlorophenoxy)methyl]-5-hydroxy-4H-pyran-4-one
-
 Homo sapiens
1.4.3.3 2-[(4-fluorophenoxy)methyl]-5-hydroxy-4H-pyran-4-one
-
 Homo sapiens
1.4.3.3 2-[(benzyloxy)methyl]-5-hydroxy-4H-pyran-4-one
-
 Homo sapiens
1.4.3.3 2-[[(3,4-dichlorophenyl)sulfanyl]methyl]-5-hydroxy-4H-pyran-4-one
-
 Homo sapiens
1.4.3.3 2-[[(4-chlorophenyl)sulfanyl]methyl]-5-hydroxy-4H-pyran-4-one
-
 Homo sapiens
1.4.3.3 2-[[(4-fluorophenyl)sulfanyl]methyl]-5-hydroxy-4H-pyran-4-one
-
 Homo sapiens
1.4.3.3 3-hydroxychromen-2-one
-
 Homo sapiens
1.4.3.3 3-hydroxyquinolin-2(1H)-one
-
 Homo sapiens
1.4.3.3 4,6-difluoro-1-hydroxy-1H-benzo[d]imidazol-2(3H)-one
-
 Homo sapiens
1.4.3.3 5-hydroxy-2-(2-phenylethyl)-4H-pyran-4-one
-
 Homo sapiens
1.4.3.3 5-hydroxy-2-(methoxymethyl)-4H-pyran-4-one
-
 Homo sapiens
1.4.3.3 5-hydroxy-2-(phenoxymethyl)-4H-pyran-4-one
-
 Homo sapiens
1.4.3.3 5-hydroxy-2-[(naphthalen-1-yloxy)methyl]-4H-pyran-4-one
-
 Homo sapiens
1.4.3.3 5-hydroxy-2-[(naphthalen-2-yloxy)methyl]-4H-pyran-4-one
-
 Homo sapiens
1.4.3.3 5-hydroxy-2-[(phenylsulfanyl)methyl]-4H-pyran-4-one
-
 Homo sapiens
1.4.3.3 5-hydroxy-2-[(pyridin-3-yloxy)methyl]-4H-pyran-4-one
-
 Homo sapiens
1.4.3.3 5-hydroxy-2-[(pyrimidin-2-ylsulfanyl)methyl]-4H-pyran-4-one
-
 Homo sapiens
1.4.3.3 6-chlorobenzo[d]isoxazol-3-ol
-
 Homo sapiens
1.4.3.3 benzoate
-
 Homo sapiens
1.4.3.3 kojic acid
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.4.3.3 D-amino acid + H2O + O2 Homo sapiens
-
 2-oxocarboxylate + NH3 + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.3 Homo sapiens P14920
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.3 D-amino acid + H2O + O2
-
 Homo sapiens 2-oxocarboxylate + NH3 + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.4.3.3 D-amino acid oxidase
-
 Homo sapiens
1.4.3.3 DAAO
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.4.3.3 FAD
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.4.3.3 0.0001
-
 pH and temperature not specified in the publication Homo sapiens 2-[[(3,4-dichlorophenyl)sulfanyl]methyl]-5-hydroxy-4H-pyran-4-one
1.4.3.3 0.0002
-
 pH and temperature not specified in the publication Homo sapiens 2-[[(4-chlorophenyl)sulfanyl]methyl]-5-hydroxy-4H-pyran-4-one
1.4.3.3 0.0002
-
 pH and temperature not specified in the publication Homo sapiens 5-hydroxy-2-[(phenylsulfanyl)methyl]-4H-pyran-4-one
1.4.3.3 0.0003
-
 pH and temperature not specified in the publication Homo sapiens 2-[[(4-fluorophenyl)sulfanyl]methyl]-5-hydroxy-4H-pyran-4-one
1.4.3.3 0.0005
-
 pH and temperature not specified in the publication Homo sapiens 2-[(3,4-dichlorophenoxy)methyl]-5-hydroxy-4H-pyran-4-one
1.4.3.3 0.0005
-
 pH and temperature not specified in the publication Homo sapiens 5-hydroxy-2-(2-phenylethyl)-4H-pyran-4-one
1.4.3.3 0.0007
-
 pH and temperature not specified in the publication Homo sapiens 2-[(4-chlorophenoxy)methyl]-5-hydroxy-4H-pyran-4-one
1.4.3.3 0.0008
-
 pH and temperature not specified in the publication Homo sapiens 2-[(4-fluorophenoxy)methyl]-5-hydroxy-4H-pyran-4-one
1.4.3.3 0.0008
-
 pH and temperature not specified in the publication Homo sapiens 5-hydroxy-2-[(naphthalen-2-yloxy)methyl]-4H-pyran-4-one
1.4.3.3 0.0009
-
 pH and temperature not specified in the publication Homo sapiens 5-hydroxy-2-(phenoxymethyl)-4H-pyran-4-one
1.4.3.3 0.0009
-
 pH and temperature not specified in the publication Homo sapiens 5-hydroxy-2-[(naphthalen-1-yloxy)methyl]-4H-pyran-4-one
1.4.3.3 0.002
-
 pH and temperature not specified in the publication Homo sapiens kojic acid
1.4.3.3 0.003
-
 pH and temperature not specified in the publication Homo sapiens 5-hydroxy-2-[(pyridin-3-yloxy)methyl]-4H-pyran-4-one
1.4.3.3 0.004
-
 pH and temperature not specified in the publication Homo sapiens 5-hydroxy-2-[(pyrimidin-2-ylsulfanyl)methyl]-4H-pyran-4-one
1.4.3.3 0.02
-
 pH and temperature not specified in the publication Homo sapiens 2-[(benzyloxy)methyl]-5-hydroxy-4H-pyran-4-one
1.4.3.3 0.05
-
 pH and temperature not specified in the publication Homo sapiens 5-hydroxy-2-(methoxymethyl)-4H-pyran-4-one