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Literature summary extracted from

  • Fender, J.E.; Bender, C.M.; Stella, N.A.; Lahr, R.M.; Kalivoda, E.J.; Shanks, R.M.
    Serratia marcescens quinoprotein glucose dehydrogenase activity mediates medium acidification and inhibition of prodigiosin production by glucose (2012), Appl. Environ. Microbiol., 78, 6225-6235.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.5.2 gene gdhS, expressionin Escherichia coli strain S17-1 Serratia marcescens

Protein Variants

EC Number Protein Variants Comment Organism
1.1.5.2 additional information complementation of the rig-10 mutant, DELTAcrp gdhS, glucose insensitivity phenotype using the wild-type Serratia marcescens gdhS gene or the Escherichia coli gcd gene expressed from a medium-copy-number plasmid Serratia marcescens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.5.2 D-glucose + ubiquinone Serratia marcescens
-
 D-glucono-1,5-lactone + ubiquinol
-
 ?
1.1.5.2 D-glucose + ubiquinone Serratia marcescens CMS2526
-
 D-glucono-1,5-lactone + ubiquinol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.5.2 Serratia marcescens
-
 gene gdhS
-
1.1.5.2 Serratia marcescens CMS2526
-
 gene gdhS
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.5.2 D-glucose + ubiquinone
-
 Serratia marcescens D-glucono-1,5-lactone + ubiquinol
-
 ?
1.1.5.2 D-glucose + ubiquinone
-
 Serratia marcescens CMS2526 D-glucono-1,5-lactone + ubiquinol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.5.2 QGDH
-
 Serratia marcescens
1.1.5.2 quinoprotein glucose dehydrogenase
-
 Serratia marcescens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.5.2 pyrroloquinoline quinone quinoprotein, required for QGDH activity Serratia marcescens

General Information

EC Number General Information Comment Organism
1.1.5.2 physiological function multiple genetic loci involved in quinoprotein glucose dehydrogenase activity are required for glucose inhibition of prodigiosin production, including pyrroloquinoline quinone and ubiquinone biosynthetic genes. The enzymatic products of GDH activity are involved in the inhibitory effect. D-Glucono-1,5-lactone and D-gluconic acid, but not D-gluconate, are able to inhibit prodigiosin production. Oxidation of D-glucose by quinoprotein GDH initiates a reduction in pH that inhibits prodigiosin production through transcriptional control of the prodigiosin biosynthetic operon Serratia marcescens