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Literature summary extracted from

  • Tandogan, B.; Guevenc, A.; Calis, I.; Ulusu, N.N.
    In vitro effects of compounds isolated from Sideritis brevibracteata on bovine kidney cortex glutathione reductase (2011), Acta Biochim. Pol., 58, 471-475.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.8.1.7 3'-hydroxy-4'-O-methylisoscutellarein 7-O-[6'''-O-acetyl-beta-D-allopyranosyl-(1->2)]-beta-D-glucopyranoside
-
 Bos taurus
1.8.1.7 hypolaetin 7-O-[6'''-O-acetyl-beta-D-allopyranosyl-(1->2)]-beta-D-glucopyranoside
-
 Bos taurus
1.8.1.7 isoscutellarein 7-O-[6'''-O-acetyl-beta-D-allopyranosyl-(1->2)]-beta-D-glucopyranoside
-
 Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.8.1.7 glutathione disulfide + NADPH + H+ Bos taurus
-
 glutathione + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.7 Bos taurus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.8.1.7 2',5'-ADP Sepharose 4B affinity chromatography and DEAE Sepharose column chromatography Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.1.7 renal cortex
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.7 glutathione disulfide + NADPH + H+
-
 Bos taurus glutathione + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.1.7 EC 1.6.4.2 formerly Bos taurus

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.1.7 flavin
-
 Bos taurus
1.8.1.7 NADPH
-
 Bos taurus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.8.1.7 0.177
-
 in 100 mM sodium phosphate buffer, pH 7.4, at 37°C Bos taurus hypolaetin 7-O-[6'''-O-acetyl-beta-D-allopyranosyl-(1->2)]-beta-D-glucopyranoside
1.8.1.7 0.295
-
 in 100 mM sodium phosphate buffer, pH 7.4, at 37°C Bos taurus 3'-hydroxy-4'-O-methylisoscutellarein 7-O-[6'''-O-acetyl-beta-D-allopyranosyl-(1->2)]-beta-D-glucopyranoside
1.8.1.7 0.372
-
 in 100 mM sodium phosphate buffer, pH 7.4, at 37°C Bos taurus isoscutellarein 7-O-[6'''-O-acetyl-beta-D-allopyranosyl-(1->2)]-beta-D-glucopyranoside