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Literature summary extracted from

  • Schachter, H.
    Mgat1-dependent N-glycans are essential for the normal development of both vertebrate and invertebrate metazoans (2010), Semin. Cell Dev. Biol., 21, 609-615.
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.101 Caenorhabditis elegans
-
-
-
2.4.1.101 Drosophila melanogaster
-
-
-
2.4.1.101 Mus musculus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.101 UDP-N-acetyl-D-glucosamine + Manalpha(1-3)Manalpha(1-6)[Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc-R
-
 Drosophila melanogaster UDP + Manalpha(1-3)Manalpha(1-6)[GlcNAcbeta(1-2)Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc-R
-
 ?
2.4.1.101 UDP-N-acetyl-D-glucosamine + Manalpha(1-3)Manalpha(1-6)[Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc-R
-
 Mus musculus UDP + Manalpha(1-3)Manalpha(1-6)[GlcNAcbeta(1-2)Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc-R
-
 ?
2.4.1.101 UDP-N-acetyl-D-glucosamine + Manalpha(1-3)Manalpha(1-6)[Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc-R
-
 Caenorhabditis elegans UDP + Manalpha(1-3)Manalpha(1-6)[GlcNAcbeta(1-2)Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc-R
-
 ?
2.4.1.101 UDP-N-acetyl-D-glucosamine + Manalpha(1-6)[Manalpha(1-3)]Manalpha(1-6)[Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc-R
-
 Drosophila melanogaster UDP + Manalpha(1-6)[Manalpha(1-3)]Manalpha(1-6)[GlcNAcbeta(1-2)Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc-R
-
 ?
2.4.1.101 UDP-N-acetyl-D-glucosamine + Manalpha(1-6)[Manalpha(1-3)]Manalpha(1-6)[Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc-R
-
 Mus musculus UDP + Manalpha(1-6)[Manalpha(1-3)]Manalpha(1-6)[GlcNAcbeta(1-2)Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc-R
-
 ?
2.4.1.101 UDP-N-acetyl-D-glucosamine + Manalpha(1-6)[Manalpha(1-3)]Manalpha(1-6)[Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc-R
-
 Caenorhabditis elegans UDP + Manalpha(1-6)[Manalpha(1-3)]Manalpha(1-6)[GlcNAcbeta(1-2)Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc-R
-
 ?
2.4.1.101 UDP-N-acetyl-D-glucosamine + Manalpha(1-6)[Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc-R
-
 Drosophila melanogaster UDP + Manalpha(1-6)[GlcNAcbeta(1-2)Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc-R
-
 ?
2.4.1.101 UDP-N-acetyl-D-glucosamine + Manalpha(1-6)[Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc-R
-
 Mus musculus UDP + Manalpha(1-6)[GlcNAcbeta(1-2)Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc-R
-
 ?
2.4.1.101 UDP-N-acetyl-D-glucosamine + Manalpha(1-6)[Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc-R
-
 Caenorhabditis elegans UDP + Manalpha(1-6)[GlcNAcbeta(1-2)Manalpha(1-3)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc-R
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.101 gly-12
-
 Caenorhabditis elegans
2.4.1.101 GLY-13
-
 Caenorhabditis elegans
2.4.1.101 gly-14
-
 Caenorhabditis elegans
2.4.1.101 GnTI
-
 Drosophila melanogaster
2.4.1.101 GnTI
-
 Mus musculus
2.4.1.101 GnTI
-
 Caenorhabditis elegans
2.4.1.101 MGAT1
-
 Drosophila melanogaster
2.4.1.101 MGAT1
-
 Mus musculus
2.4.1.101 MGAT1
-
 Caenorhabditis elegans
2.4.1.101 UDP-GlcNAc:alpha3-D-mannoside beta1,2-N-acetylglucosaminyltransferase I
-
 Drosophila melanogaster
2.4.1.101 UDP-GlcNAc:alpha3-D-mannoside beta1,2-N-acetylglucosaminyltransferase I
-
 Mus musculus
2.4.1.101 UDP-GlcNAc:alpha3-D-mannoside beta1,2-N-acetylglucosaminyltransferase I
-
 Caenorhabditis elegans

General Information

EC Number General Information Comment Organism
2.4.1.101 malfunction Mgat1-null flies are viable but exhibit pronounced defects in locomotion. Neuron-specific RNAi knockdown of Mgat1 in wild-type flies results in locomotory defects, reduced life span, and about 50% reduction in enzyme activity Drosophila melanogaster
2.4.1.101 malfunction Mgat1-null mouse embryos die at 9.5-10.5 days after fertilization Mus musculus
2.4.1.101 malfunction worms with either deletion or RNA-mediated down-regulation of the gly-14 gene are completely resistant to killing by bacteria on PGS medium Caenorhabditis elegans
2.4.1.101 physiological function Mgat1-dependent N-glycans are required for normal development Drosophila melanogaster
2.4.1.101 physiological function Mgat1-dependent N-glycans are required for normal development Mus musculus
2.4.1.101 physiological function Mgat1-dependent N-glycans are required for normal development Caenorhabditis elegans