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Literature summary extracted from

  • Cankaya, M.; Sisecioglu, M.; Ciftci, M.; Ozdemir, H.
    Effects of some metal ions on trout liver glucose 6-phosphate dehydrogenase (2011), Res. J. Environ. Toxicol., 5, 385-391.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.49 Cd2+ noncompetitive inhibition Oncorhynchus mykiss
1.1.1.49 Cu2+ noncompetitive inhibition Oncorhynchus mykiss
1.1.1.49 Fe2+ strong competitive inhibition Oncorhynchus mykiss
1.1.1.49 Hg2+ noncompetitive inhibition Oncorhynchus mykiss
1.1.1.49 Pb2+ noncompetitive inhibition Oncorhynchus mykiss
1.1.1.49 Zn2+ noncompetitive inhibition Oncorhynchus mykiss

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.49 48500
-
 x * 48500, SDS-PAGE Oncorhynchus mykiss

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.49 D-glucose 6-phosphate + NADP+ Oncorhynchus mykiss
-
 D-glucono-1,5-lactone 6-phosphate + NADPH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.49 Oncorhynchus mykiss
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.49 native enzyme 1010fold from liver by 2',5'-ADP affinity chromatography Oncorhynchus mykiss

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.49 liver
-
 Oncorhynchus mykiss
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.49 36.25
-
 purified enzyme, pH 6.0, 25°C Oncorhynchus mykiss

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.49 D-glucose 6-phosphate + NADP+
-
 Oncorhynchus mykiss D-glucono-1,5-lactone 6-phosphate + NADPH + H+
-
 ?

Subunits

EC Number Subunits Comment Organism
1.1.1.49 ? x * 48500, SDS-PAGE Oncorhynchus mykiss

Synonyms

EC Number Synonyms Comment Organism
1.1.1.49 G6PD
-
 Oncorhynchus mykiss
1.1.1.49 glucose 6-phosphate dehydrogenase
-
 Oncorhynchus mykiss

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.49 25
-
 assay at Oncorhynchus mykiss

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.49 6
-
 assay at Oncorhynchus mykiss

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.49 NADP+
-
 Oncorhynchus mykiss

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.1.1.49 0.197
-
 Fe2+ pH 6.0, 25°C Oncorhynchus mykiss
1.1.1.49 0.213
-
 Pb2+ pH 6.0, 25°C Oncorhynchus mykiss
1.1.1.49 0.542
-
 Hg2+ pH 6.0, 25°C Oncorhynchus mykiss
1.1.1.49 1.721
-
 Cu2+ pH 6.0, 25°C Oncorhynchus mykiss
1.1.1.49 2.034
-
 Cd2+ pH 6.0, 25°C Oncorhynchus mykiss
1.1.1.49 2.77
-
 Zn2+ pH 6.0, 25°C Oncorhynchus mykiss

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.1.1.49 0.39
-
 pH 6.0, 25°C Oncorhynchus mykiss Fe2+
1.1.1.49 0.78
-
 pH 6.0, 25°C Oncorhynchus mykiss Pb2+
1.1.1.49 0.87
-
 pH 6.0, 25°C Oncorhynchus mykiss Hg2+
1.1.1.49 1.19
-
 pH 6.0, 25°C Oncorhynchus mykiss Cu2+
1.1.1.49 1.97
-
 pH 6.0, 25°C Oncorhynchus mykiss Cd2+
1.1.1.49 2.16
-
 pH 6.0, 25°C Oncorhynchus mykiss Zn2+

General Information

EC Number General Information Comment Organism
1.1.1.49 metabolism rate-limiting enzyme of the pentose-phosphate pathway Oncorhynchus mykiss