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Literature summary extracted from

  • Koldobskiy, M.A.; Chakraborty, A.; Werner, J.K.; Snowman, A.M.; Juluri, K.R.; Vandiver, M.S.; Kim, S.; Heletz, S.; Snyder, S.H.
    p53-mediated apoptosis requires inositol hexakisphosphate kinase-2 (2010), Proc. Natl. Acad. Sci. USA, 107, 20947-20951.
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
2.7.4.21 Homo sapiens
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-
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.4.21 colorectal cancer cell
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Homo sapiens
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2.7.4.21 HCT-116 cell
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Homo sapiens
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.4.21 ATP + 1D-myo-inositol hexakisphosphate
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Homo sapiens ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)-pentakisphosphate
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Synonyms

EC Number Synonyms Comment Organism
2.7.4.21 inositol hexakisphosphate kinase-2
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Homo sapiens
2.7.4.21 IP6K2
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Homo sapiens

General Information

EC Number General Information Comment Organism
2.7.4.21 malfunction gene disruption of isoform IP6K2 in colorectal cancer cells selectively impairs p53-mediated apoptosis, instead favoring cell-cycle arrest Homo sapiens
2.7.4.21 physiological function isoform IP6K2 is required for p53-mediated apoptosis and modulates the outcome of the p53 response. IP6K2 acts by binding directly to p53 and decreasing expression of proarrest gene targets such as the cyclin-dependent kinase inhibitor p21 Homo sapiens