EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.4.21 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.4.21 | colorectal cancer cell | - |
Homo sapiens | - |
2.7.4.21 | HCT-116 cell | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.4.21 | ATP + 1D-myo-inositol hexakisphosphate | - |
Homo sapiens | ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)-pentakisphosphate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.4.21 | inositol hexakisphosphate kinase-2 | - |
Homo sapiens |
2.7.4.21 | IP6K2 | - |
Homo sapiens |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.7.4.21 | malfunction | gene disruption of isoform IP6K2 in colorectal cancer cells selectively impairs p53-mediated apoptosis, instead favoring cell-cycle arrest | Homo sapiens |
2.7.4.21 | physiological function | isoform IP6K2 is required for p53-mediated apoptosis and modulates the outcome of the p53 response. IP6K2 acts by binding directly to p53 and decreasing expression of proarrest gene targets such as the cyclin-dependent kinase inhibitor p21 | Homo sapiens |