Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Sarmah, B.; Wente, S.R.
    Inositol hexakisphosphate kinase-2 acts as an effector of the vertebrate Hedgehog pathway (2010), Proc. Natl. Acad. Sci. USA, 107, 19921-19926.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.4.21 N2-(3-(trifluoromethyl)benzyl)-N6-(4-nitrobenzyl)purine
-
 Danio rerio

Organism

EC Number Organism UniProt Comment Textmining
2.7.4.21 Danio rerio
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.4.21 embryo
-
 Danio rerio
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.4.21 ATP + 1D-myo-inositol hexakisphosphate
-
 Danio rerio ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)-pentakisphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.4.21 inositol hexakisphosphate kinase-2
-
 Danio rerio
2.7.4.21 IP6K2
-
 Danio rerio

General Information

EC Number General Information Comment Organism
2.7.4.21 malfunction isoform IP6K2 depletion inhibits Hh target gene expression. Inhibiting enzyme activity results in altered Hedgehog signal transduction. Isoform IP6K2 knockdown alters craniofacial and somite structures and inhibits the development and migration of neural crest cells Danio rerio
2.7.4.21 metabolism isoform inositol hexakisphosphate kinase-2 acts as an effector of the vertebrate Hedgehog pathway. IP6K2 activity is required at the level or downstream of Smoothened but upstream of the transcription activator Gli1 Danio rerio
2.7.4.21 physiological function isoform P6K2 activity is required for normal development of craniofacial structures, somites, and neural crest cells Danio rerio