EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
2.5.1.78 | W22A | single amino acid mutation located in the active site of the endogenous RibH2. Mutant lacks enzymatic activity but its stability and structure are unaltered | Brucella abortus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.5.1.78 | Brucella abortus | P61711 | isoform RibH2 | - |
2.5.1.78 | Brucella abortus | Q57DY1 | isoform RibH1 | - |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.5.1.78 | luminazine synthase | - |
Brucella abortus |
2.5.1.78 | ribH1 | - |
Brucella abortus |
2.5.1.78 | RibH2 | - |
Brucella abortus |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.5.1.78 | physiological function | disruption mutants of either isform RibH1 or RibH2 obtained without any major difficulty, are not auxotrophic for riboflavin and grow at wild-type rates in both rich and minimal media. A double mutant lacking both RibH1 and RibH2 activity is not viable | Brucella abortus |
2.5.1.78 | physiological function | disruption mutants of either isform RibH1 or RibH2 obtained without any major difficulty, are not auxotrophic for riboflavin and grow at wild-type rates in both rich and minimal media. A double mutant lacking both RibH1 and RibH2 activity is not viable. For virulence, at least one isoform must be present for Brucella abortus survival and RibH2 and not RibH1 is essential for intracellular survival due to its luminazine synthase activity in vivo. | Brucella abortus |