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Literature summary extracted from

  • Sun, J.; Wang, X.; Lau, A.; Liao, T.Y.; Bucci, C.; Hmama, Z.
    Mycobacterial nucleoside diphosphate kinase blocks phagosome maturation in murine RAW 264.7 macrophages (2010), PLoS ONE, 5, e8769.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.4.6 ATP + NDP Mycobacterium tuberculosis
-
 ADP + NTP
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.4.6 Mycobacterium tuberculosis
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.4.6 ATP + GDP
-
 Mycobacterium tuberculosis ADP + GTP
-
 ?
2.7.4.6 ATP + NDP
-
 Mycobacterium tuberculosis ADP + NTP
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.4.6 ? x * about 15000, SDS-PAGE Mycobacterium tuberculosis

Synonyms

EC Number Synonyms Comment Organism
2.7.4.6 NDK
-
 Mycobacterium tuberculosis
2.7.4.6 nucleoside diphosphate kinase
-
 Mycobacterium tuberculosis

General Information

EC Number General Information Comment Organism
2.7.4.6 physiological function nucleoside diphosphate kinase exhibits GTPase activating protein activity towards Rab5 and Rab7. The enzyme is a putative virulence factor that inhibits phagosome maturation and promotes survival of mycobacteria within the macrophage Mycobacterium tuberculosis