EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.21 | 3'-azido-2',3'-dideoxy-3,4-dihydrothymidine | stimulates deoxycytidine phosphorylation catalyzed by thymidine kinase 2 | Rattus norvegicus | |
2.7.1.21 | 3'-azido-3'-deoxythymidine | stimulates deoxycytidine phosphorylation catalyzed by thymidine kinase 2 | Homo sapiens | |
2.7.1.21 | 3'-deoxy-3'-fluorothymidine | stimulates deoxycytidine phosphorylation catalyzed by thymidine kinase 2 | Homo sapiens | |
2.7.1.21 | 3'-fluorothymidine | stimulates deoxycytidine phosphorylation catalyzed by thymidine kinase 2 | Rattus norvegicus |
EC Number | Cloned (Comment) | Organism |
---|---|---|
2.7.1.21 | expressed in Escherichia coli | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.21 | 3'-azido-2',3'-dideoxy-3,4-dihydrothymidine | inhibits thymidine phosphorylation catalyzed by thymidine kinase 2 | Homo sapiens | |
2.7.1.21 | 3'-azido-2',3'-dideoxy-3,4-dihydrothymidine | inhibits thymidine phosphorylation catalyzed by thymidine kinase 2 | Rattus norvegicus | |
2.7.1.21 | 3'-deoxy-3'-fluorothymidine | inhibits thymidine phosphorylation catalyzed by thymidine kinase 2 | Homo sapiens | |
2.7.1.21 | 3'-fluorothymidine | inhibits thymidine phosphorylation catalyzed by thymidine kinase 2 | Rattus norvegicus | |
2.7.1.21 | additional information | at physiological relevant concentration deoxycytidine phosphorylation is not inhibited by 3-azido-3'-deoxythmidine or 3'-fluorothymidine | Homo sapiens | |
2.7.1.21 | additional information | at physiological relevant concentration deoxycytidine phosphorylation is not inhibited by 3'-azido-3'-deoxythmidine or 3'-fluorothymidine | Rattus norvegicus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.1.21 | 0.0188 | - |
thymidine | pH and temperature not specified in the publication | Rattus norvegicus | |
2.7.1.21 | 0.0414 | - |
deoxycytidine | pH and temperature not specified in the publication | Rattus norvegicus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.7.1.21 | mitochondrion | - |
Homo sapiens | 5739 | - |
2.7.1.21 | mitochondrion | - |
Rattus norvegicus | 5739 | - |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.1.21 | Homo sapiens | - |
- |
- |
2.7.1.21 | Rattus norvegicus | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.7.1.21 | - |
Homo sapiens |
2.7.1.21 | DEAE-Sephadex gel filtration | Rattus norvegicus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.1.21 | liver | - |
Homo sapiens | - |
2.7.1.21 | liver | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.21 | ATP + deoxycytidine | - |
Homo sapiens | ADP + dCMP | - |
? | |
2.7.1.21 | ATP + deoxycytidine | - |
Rattus norvegicus | ADP + dCMP | - |
? | |
2.7.1.21 | ATP + thymidine | - |
Homo sapiens | ADP + dTMP | - |
? | |
2.7.1.21 | ATP + thymidine | - |
Rattus norvegicus | ADP + dTMP | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.1.21 | thymidine kinase 2 | - |
Homo sapiens |
2.7.1.21 | thymidine kinase 2 | - |
Rattus norvegicus |
2.7.1.21 | TK2 | - |
Homo sapiens |
2.7.1.21 | TK2 | - |
Rattus norvegicus |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.1.21 | 0.0014 | - |
3'-deoxy-3'-fluorothymidine | pH and temperature not specified in the publication | Homo sapiens | |
2.7.1.21 | 0.0014 | - |
3'-fluorothymidine | pH and temperature not specified in the publication | Rattus norvegicus | |
2.7.1.21 | 0.0039 | - |
3'-azido-2',3'-dideoxy-3,4-dihydrothymidine | pH and temperature not specified in the publication | Homo sapiens | |
2.7.1.21 | 0.0039 | - |
3'-azido-2',3'-dideoxy-3,4-dihydrothymidine | pH and temperature not specified in the publication | Rattus norvegicus |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.7.1.21 | physiological function | thymidine kinase 2 plays an important role in providing precursors for the replication and maintenance of mitochondrial DNA, especially in nonproliferating cells | Homo sapiens |
2.7.1.21 | physiological function | thymidine kinase 2 plays an important role in providing precursors for the replication and maintenance of mitochondrial DNA, especially in nonproliferating cells | Rattus norvegicus |