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Literature summary extracted from

  • Forsman, U.; Sjoeberg, M.; Turunen, M.; Sindelar, P.J.
    4-Nitrobenzoate inhibits coenzyme Q biosynthesis in mammalian cell cultures (2010), Nat. Chem. Biol., 6, 515-517.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.39 4-nitrobenzoate competitive enzyme inhibition, cell treatement with 4-nitrobenzoate leads to a decrease in coenzyme Q content, but 4-nitrobenzoate treatment has no apparent toxic effect on the cells and does not decrease Q concentration by inducing oxidative stress Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.5.1.39 mitochondrial membrane
-
 Mus musculus 31966
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.39 a polyprenyl diphosphate + 4-hydroxybenzoate Mus musculus
-
 diphosphate + a 4-hydroxy-3-polyprenylbenzoate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.39 Mus musculus
-
 gene COQ2
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.5.1.39 fibroblast
-
 Mus musculus
-
2.5.1.39 Swiss-3T3 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.39 a polyprenyl diphosphate + 4-hydroxybenzoate
-
 Mus musculus diphosphate + a 4-hydroxy-3-polyprenylbenzoate
-
 ?
2.5.1.39 a polyprenyl diphosphate + 4-hydroxybenzoate Coq2 is quite unspecific with regard to its substrates Mus musculus diphosphate + a 4-hydroxy-3-polyprenylbenzoate
-
 ?
2.5.1.39 geranyl diphosphate + 4-hydroxybenzoate
-
 Mus musculus diphosphate + 3-geranyl-4-hydroxybenzoate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.39 4-hydroxybenzoate:polyprenyl transferase
-
 Mus musculus
2.5.1.39 COQ2
-
 Mus musculus

General Information

EC Number General Information Comment Organism
2.5.1.39 physiological function Coq2 plays an important role in coenzyme Q metabolism Mus musculus