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Literature summary extracted from

  • Awasthy, D.; Ambady, A.; Bhat, J.; Sheikh, G.; Ravishankar, S.; Subbulakshmi, V.; Mukherjee, K.; Sambandamurthy, V.; Sharma, U.
    Essentiality and functional analysis of type I and type III pantothenate kinases of Mycobacterium tuberculosis (2010), Microbiology, 156, 2691-2701.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.33 expressed in Escherichia coli DV62 and BL21(DE3) cells Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.33 Mycobacterium tuberculosis
-
-
-
2.7.1.33 Mycobacterium tuberculosis H37Rv (ATCC 27294)
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.33 Ni-NTA column chromatography and Superdex pg 200 gel filtration Mycobacterium tuberculosis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.33 ATP + (R)-pantothenate
-
Mycobacterium tuberculosis ADP + (R)-4'-phosphopantothenate
-
?
2.7.1.33 ATP + (R)-pantothenate
-
Mycobacterium tuberculosis H37Rv (ATCC 27294) ADP + (R)-4'-phosphopantothenate
-
?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.33 CoaA isoform, CoaA is the essential pantothenate kinase in Mycobacterium tuberculosis Mycobacterium tuberculosis
2.7.1.33 CoaX isoform Mycobacterium tuberculosis

General Information

EC Number General Information Comment Organism
2.7.1.33 physiological function CoaA is essential for survival of Mycobacterium tuberculosis. The coax gene is unable to complement the loss of gene coaA. CoaX lacks pantothenate kinase activity in vitro and is not required for survival in macrophages and mice Mycobacterium tuberculosis