EC Number | Cloned (Comment) | Organism |
---|---|---|
2.7.1.33 | expressed in Escherichia coli DV62 and BL21(DE3) cells | Mycobacterium tuberculosis |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.1.33 | Mycobacterium tuberculosis | - |
- |
- |
2.7.1.33 | Mycobacterium tuberculosis H37Rv (ATCC 27294) | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.7.1.33 | Ni-NTA column chromatography and Superdex pg 200 gel filtration | Mycobacterium tuberculosis |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.33 | ATP + (R)-pantothenate | - |
Mycobacterium tuberculosis | ADP + (R)-4'-phosphopantothenate | - |
? | |
2.7.1.33 | ATP + (R)-pantothenate | - |
Mycobacterium tuberculosis H37Rv (ATCC 27294) | ADP + (R)-4'-phosphopantothenate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.1.33 | CoaA | isoform, CoaA is the essential pantothenate kinase in Mycobacterium tuberculosis | Mycobacterium tuberculosis |
2.7.1.33 | CoaX | isoform | Mycobacterium tuberculosis |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.7.1.33 | physiological function | CoaA is essential for survival of Mycobacterium tuberculosis. The coax gene is unable to complement the loss of gene coaA. CoaX lacks pantothenate kinase activity in vitro and is not required for survival in macrophages and mice | Mycobacterium tuberculosis |