EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.292 | S-adenosyl-L-methionine + carminomycin | Streptomyces sp. | with the corresponding aglycones, carminomycinone and 13-dihydrocarminomycinone, as substrates, no methylated products are detected. Other 4-hydroxyanthracyclines such as aklavin and aclacinomycin A, and 4-hydroxyanthracyclinones such as erhodomycinone and aklavinone, are not substrates for the 4-O-methyltransferase. These reaction specificities indicate that glycosylation of the anthracyclinone molecule must occur before 4-O-methylation, which means that 4-O-methylation of carminomycin is probably the terminal step in the biosynthesis of daunomycin, and that daunomycinone is not an intermediate in the pathway | S-adenosyl-L-homocysteine + daunomycin | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.1.1.292 | Streptomyces sp. | Q55216 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.292 | S-adenosyl-L-methionine + 13-dihydrocarminomycin | - |
Streptomyces sp. | S-adenosyl-L-homocysteine + daunorubicinol | - |
? | |
2.1.1.292 | S-adenosyl-L-methionine + carminomycin | - |
Streptomyces sp. | S-adenosyl-L-homocysteine + daunomycin | - |
? | |
2.1.1.292 | S-adenosyl-L-methionine + carminomycin | with the corresponding aglycones, carminomycinone and 13-dihydrocarminomycinone, as substrates, no methylated products are detected. Other 4-hydroxyanthracyclines such as aklavin and aclacinomycin A, and 4-hydroxyanthracyclinones such as erhodomycinone and aklavinone, are not substrates for the 4-O-methyltransferase. These reaction specificities indicate that glycosylation of the anthracyclinone molecule must occur before 4-O-methylation, which means that 4-O-methylation of carminomycin is probably the terminal step in the biosynthesis of daunomycin, and that daunomycinone is not an intermediate in the pathway | Streptomyces sp. | S-adenosyl-L-homocysteine + daunomycin | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.1.1.292 | COMT | - |
Streptomyces sp. |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.1.1.292 | physiological function | the enzyme catalyzes the terminal enzymic step in the formation of daunomycin | Streptomyces sp. |