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Literature summary extracted from

  • Jadav, R.S.; Chanduri, M.V.; Sengupta, S.; Bhandari, R.
    Inositol pyrophosphate synthesis by inositol hexakisphosphate kinase 1 is required for homologous recombination repair (2013), J. Biol. Chem., 288, 3312-3321.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
2.7.4.21 K226A/S334A catalytically inactive Mus musculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.4.21 50000
-
 x * 50000, isoform IP6K1, SDS-PAGE Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
2.7.4.21 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.4.21 MEF cell
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.4.21 ATP + 1D-myo-inositol hexakisphosphate
-
 Mus musculus ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)-pentakisphosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.4.21 ? x * 50000, isoform IP6K1, SDS-PAGE Mus musculus

Synonyms

EC Number Synonyms Comment Organism
2.7.4.21 inositol hexakisphosphate kinase 1 isoform Mus musculus
2.7.4.21 IP6K1 isoform Mus musculus

General Information

EC Number General Information Comment Organism
2.7.4.21 malfunction cells lacking isoform IP6K1 arrest after genotoxic stress, and markers associated with DNA repair are recruited to DNAdamage sites indicating that homologous recombination repair is initiated in these cells. However, repair does not proceed to completion. Enzyme loss increases chromosomal damage susceptibility Mus musculus
2.7.4.21 physiological function loss of inositol pyrophosphate synthesis by inositol hexakisphosphate kinase 1 impairs homologous recombination in mammalian cells, leading to increased cell death Mus musculus