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Literature summary extracted from

  • Kim, S.H.; Lee, P.C.
    Functional expression and extension of staphylococcal staphyloxanthin biosynthetic pathway in Escherichia coli (2012), J. Biol. Chem., 287, 21575-21583.
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.B23 Staphylococcus aureus A0A0H3KDU5
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.2.1.B23 4,4'-diaponeurosporen-4-al + NAD(P)+ = 4,4'-diaponeurosporenoic acid + NAD(P)H + H+ broad substrate specificity, in addition catalyzes synthesis of 4,4'-diapolycopen-4'-al-4-oic acid and 4,4'-diapolycopenoic acid from the respective aldehydes Staphylococcus aureus
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.B23 4,4'-diapolycopen-4'-al-4-oic acid + NAD(P)+
-
 Staphylococcus aureus 4,4'-diapolycopen-4,4'-dioic acid + NAD(P)H + H+
-
 ?
1.2.1.B23 4,4'-diapolycopen-4-al + NAD(P)+
-
 Staphylococcus aureus 4,4'-diapolycopenoic acid + NAD(P)H + H+
-
 ?
1.2.1.B23 4,4'-diapolycopenedial + NAD(P)+
-
 Staphylococcus aureus 4,4'-diapolycopen-4'-al-4-oic acid + NAD(P)H + H+
-
 ?
1.2.1.B23 4,4'-diaponeurosporen-4-al + NAD(P)+
-
 Staphylococcus aureus 4,4'-diaponeurosporenoic acid + NAD(P)H + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.2.1.B23 ALDH
-
 Staphylococcus aureus
1.2.1.B23 NWMN_2026
-
 Staphylococcus aureus

General Information

EC Number General Information Comment Organism
1.2.1.B23 physiological function final enzyme in the biosynthetic pathway for staphyloxanthin, a C30 carotenoid biosynthesized by Staphylococcus aureus. Deletion of the gene abolishes staphyloxanthin biosynthesis and causes accumulation of 4,4'-diaponeurosporen-4-al. When the complete staphyloxanthin biosynthetic pathway is expressed using an artificial synthetic operon in Escherichia coli, staphyloxanthin-like compounds, which contain altered fatty acid acyl chains, and novel carotenoid compounds aere produced, indicating functional expression and coordination of the six staphyloxanthin pathway enzymes Staphylococcus aureus