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Literature summary extracted from

  • Liu, Z.; Swindall, A.F.; Kesterson, R.A.; Schoeb, T.R.; Bullard, D.C.; Bellis, S.L.
    ST6Gal-I regulates macrophage apoptosis via alpha2-6 sialylation of the TNFR1 death receptor (2011), J. Biol. Chem., 286, 39654-39662.
    View publication on PubMedView publication on EuropePMC

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.4.3.1 50000
-
 x * 50000, SDS-PAGE Homo sapiens
2.4.3.1 50000
-
 x * 50000, SDS-PAGE Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.3.1 CMP-N-acetylneuraminate + tumor necrosis factor receptor 1 Homo sapiens
-
 CMP + alpha2,6-sialyated tumor necrosis factor receptor 1
-
 ?
2.4.3.1 CMP-N-acetylneuraminate + tumor necrosis factor receptor 1 Mus musculus
-
 CMP + alpha2,6-sialyated tumor necrosis factor receptor 1
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.3.1 Homo sapiens P15907
-
-
2.4.3.1 Mus musculus Q64685
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.3.1 macrophage
-
 Mus musculus
-
2.4.3.1 monocyte
-
 Homo sapiens
-
2.4.3.1 U-937 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.3.1 CMP-N-acetylneuraminate + tumor necrosis factor receptor 1
-
 Homo sapiens CMP + alpha2,6-sialyated tumor necrosis factor receptor 1
-
 ?
2.4.3.1 CMP-N-acetylneuraminate + tumor necrosis factor receptor 1
-
 Mus musculus CMP + alpha2,6-sialyated tumor necrosis factor receptor 1
-
 ?

Subunits

EC Number Subunits Comment Organism
2.4.3.1 ? x * 50000, SDS-PAGE Homo sapiens
2.4.3.1 ? x * 50000, SDS-PAGE Mus musculus

Synonyms

EC Number Synonyms Comment Organism
2.4.3.1 beta-galactoside alpha2-6-sialyltransferase-1
-
 Homo sapiens
2.4.3.1 beta-galactoside alpha2-6-sialyltransferase-1
-
 Mus musculus
2.4.3.1 ST6Gal-I
-
 Homo sapiens
2.4.3.1 ST6Gal-I
-
 Mus musculus

General Information

EC Number General Information Comment Organism
2.4.3.1 malfunction enzyme down-regulation limits monocyte/macrophage lifespan by sensitizing cells to apoptosis via tumor necrosis factor receptor I hyposialylation Homo sapiens
2.4.3.1 malfunction enzyme down-regulation limits monocyte/macrophage lifespan by sensitizing cells to apoptosis via tumor necrosis factor receptor I hyposialylation Mus musculus
2.4.3.1 physiological function the enzyme regulates macrophage tumor necrosis factor alpha-induced apoptosis via alpha2-6 sialylation of the tumor necrosis factor receptor I death receptor. The enzyme inhibits phorbol-12-myristate-13-acetate-induced suppression of cell growth Homo sapiens
2.4.3.1 physiological function the enzyme regulates macrophage tumor necrosis factor alpha-induced apoptosis via alpha2-6 sialylation of the tumor necrosis factor receptor I death receptor. The enzyme inhibits phorbol-12-myristate-13-acetate-induced suppression of cell growth Mus musculus