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Literature summary extracted from

  • Nishimura, H.; Azami, Y.; Miyagawa, M.; Hashimoto, C.; Yoshimura, T.; Hemmi, H.
    Biochemical evidence supporting the presence of the classical mevalonate pathway in the thermoacidophilic archaeon Sulfolobus solfataricus (2013), J. Biochem., 153, 415-420.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.36 expression in Escherichia coli Saccharolobus solfataricus
2.7.4.2 expression in Escherichia coli Saccharolobus solfataricus
4.1.1.33 expression in Escherichia coli Saccharolobus solfataricus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.1.36 37000
-
x * 37000, calculated from sequence Saccharolobus solfataricus
2.7.4.2 36200
-
x * 36200, calculated from sequence Saccharolobus solfataricus
4.1.1.33 37000
-
x * 37000, calculated Saccharolobus solfataricus
4.1.1.33 37028
-
x * 37028, calculated from sequence Saccharolobus solfataricus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.36 additional information Saccharolobus solfataricus the enzyme is involved in the modified mevalonate pathway. The recombinant protein is active. However in vitro conversion of the intermediates in the classical and modified pathways by cell-free extract from Sulfolobus solfataricus indicates that only the classical pathway likely works in the organism ?
-
?
2.7.1.36 additional information Saccharolobus solfataricus P2 the enzyme is involved in the modified mevalonate pathway. The recombinant protein is active. However in vitro conversion of the intermediates in the classical and modified pathways by cell-free extract from Sulfolobus solfataricus indicates that only the classical pathway likely works in the organism ?
-
?
2.7.4.2 ATP + (R)-5-phosphomevalonate Saccharolobus solfataricus the enzyme is involved in the classical mevalonate pathway ADP + (R)-5-diphosphomevalonate
-
?
2.7.4.2 ATP + (R)-5-phosphomevalonate Saccharolobus solfataricus P2 the enzyme is involved in the classical mevalonate pathway ADP + (R)-5-diphosphomevalonate
-
?
4.1.1.33 ATP + (R)-5-diphosphomevalonate Saccharolobus solfataricus the enzyme catalyzes a reaction of the classical mevalonate pathway ADP + phosphate + isopentenyl diphosphate + CO2
-
?
4.1.1.33 ATP + (R)-5-diphosphomevalonate Saccharolobus solfataricus P2 the enzyme catalyzes a reaction of the classical mevalonate pathway ADP + phosphate + isopentenyl diphosphate + CO2
-
?
4.1.1.33 ATP + (R)-5-diphosphomevalonate Saccharolobus solfataricus DSM 1617 the enzyme catalyzes a reaction of the classical mevalonate pathway ADP + phosphate + isopentenyl diphosphate + CO2
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.36 Saccharolobus solfataricus Q980D2
-
-
2.7.1.36 Saccharolobus solfataricus P2 Q980D2
-
-
2.7.4.2 Saccharolobus solfataricus Q97UL6
-
-
2.7.4.2 Saccharolobus solfataricus P2 Q97UL6
-
-
4.1.1.33 Saccharolobus solfataricus Q97UL5
-
-
4.1.1.33 Saccharolobus solfataricus DSM 1617 Q97UL5
-
-
4.1.1.33 Saccharolobus solfataricus P2 Q97UL5
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.36
-
Saccharolobus solfataricus
2.7.4.2
-
Saccharolobus solfataricus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.36 ATP + (R)-mevalonate the enzyme is involved in the modified mevalonate pathway. The recombinant protein is active. However in vitro conversion of the intermediates in the classical and modified pathways by cell-free extract from Sulfolobus solfataricus indicates that only the classical pathway likely works in the organism Saccharolobus solfataricus ADP + (R)-5-phosphomevalonate
-
?
2.7.1.36 ATP + (R)-mevalonate the enzyme is involved in the modified mevalonate pathway. The recombinant protein is active. However in vitro conversion of the intermediates in the classical and modified pathways by cell-free extract from Sulfolobus solfataricus indicates that only the classical pathway likely works in the organism Saccharolobus solfataricus P2 ADP + (R)-5-phosphomevalonate
-
?
2.7.1.36 additional information the enzyme is involved in the modified mevalonate pathway. The recombinant protein is active. However in vitro conversion of the intermediates in the classical and modified pathways by cell-free extract from Sulfolobus solfataricus indicates that only the classical pathway likely works in the organism Saccharolobus solfataricus ?
-
?
2.7.1.36 additional information the enzyme is involved in the modified mevalonate pathway. The recombinant protein is active. However in vitro conversion of the intermediates in the classical and modified pathways by cell-free extract from Sulfolobus solfataricus indicates that only the classical pathway likely works in the organism Saccharolobus solfataricus P2 ?
-
?
2.7.4.2 ATP + (R)-5-phosphomevalonate
-
Saccharolobus solfataricus ADP + (R)-5-diphosphomevalonate
-
?
2.7.4.2 ATP + (R)-5-phosphomevalonate the enzyme is involved in the classical mevalonate pathway Saccharolobus solfataricus ADP + (R)-5-diphosphomevalonate
-
?
2.7.4.2 ATP + (R)-5-phosphomevalonate
-
Saccharolobus solfataricus P2 ADP + (R)-5-diphosphomevalonate
-
?
2.7.4.2 ATP + (R)-5-phosphomevalonate the enzyme is involved in the classical mevalonate pathway Saccharolobus solfataricus P2 ADP + (R)-5-diphosphomevalonate
-
?
4.1.1.33 ATP + (R)-5-diphosphomevalonate
-
Saccharolobus solfataricus ADP + phosphate + isopentenyl diphosphate + CO2
-
?
4.1.1.33 ATP + (R)-5-diphosphomevalonate the enzyme catalyzes a reaction of the classical mevalonate pathway Saccharolobus solfataricus ADP + phosphate + isopentenyl diphosphate + CO2
-
?
4.1.1.33 ATP + (R)-5-diphosphomevalonate
-
Saccharolobus solfataricus P2 ADP + phosphate + isopentenyl diphosphate + CO2
-
?
4.1.1.33 ATP + (R)-5-diphosphomevalonate the enzyme catalyzes a reaction of the classical mevalonate pathway Saccharolobus solfataricus P2 ADP + phosphate + isopentenyl diphosphate + CO2
-
?
4.1.1.33 ATP + (R)-5-diphosphomevalonate
-
Saccharolobus solfataricus DSM 1617 ADP + phosphate + isopentenyl diphosphate + CO2
-
?
4.1.1.33 ATP + (R)-5-diphosphomevalonate the enzyme catalyzes a reaction of the classical mevalonate pathway Saccharolobus solfataricus DSM 1617 ADP + phosphate + isopentenyl diphosphate + CO2
-
?
4.1.1.33 additional information no substrate: mevalonate 5-phosphate Saccharolobus solfataricus ?
-
?
4.1.1.33 additional information no substrate: mevalonate 5-phosphate Saccharolobus solfataricus P2 ?
-
?
4.1.1.33 additional information no substrate: mevalonate 5-phosphate Saccharolobus solfataricus DSM 1617 ?
-
?

Subunits

EC Number Subunits Comment Organism
2.7.1.36 ? x * 37000, calculated from sequence Saccharolobus solfataricus
2.7.4.2 ? x * 36200, calculated from sequence Saccharolobus solfataricus
4.1.1.33 ? x * 37000, calculated Saccharolobus solfataricus
4.1.1.33 ? x * 37028, calculated from sequence Saccharolobus solfataricus

Synonyms

EC Number Synonyms Comment Organism
2.7.1.36 MVK
-
Saccharolobus solfataricus
2.7.1.36 SSO0383
-
Saccharolobus solfataricus
2.7.4.2 PMK
-
Saccharolobus solfataricus
2.7.4.2 SSO2988
-
Saccharolobus solfataricus
4.1.1.33 DMD
-
Saccharolobus solfataricus
4.1.1.33 SSO2989
-
Saccharolobus solfataricus
4.1.1.33 SSO2989 locus name Saccharolobus solfataricus

General Information

EC Number General Information Comment Organism
4.1.1.33 metabolism the enzyme catalyzes a reaction of the classical mevalonate pathway Saccharolobus solfataricus