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Literature summary extracted from

  • Dickens, M.L.; Ye, J.; Strohl, W.R.
    Cloning, sequencing, and analysis of aklaviketone reductase from Streptomyces sp. strain C5 (1996), J. Bacteriol., 178, 3384-3388.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.362 extracts of Streptomyces lividans TK24 containing recombinant DauE catalyzes the NADPH-specific conversion of aklaviketone, maggiemycin, and 7-oxodaunomycinone to aklavinone, epsilon-rhodomycinone, and daunomycinone, respectively Streptomyces sp.

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.362 25632
-
 x * 25632, calculated from sequence Streptomyces sp.

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.362 aklaviketone + NADPH + H+ Streptomyces sp. the enzyme is involved in the biosynthesis of the anthracyclins aclacinomycin and daunomycin. Aklavinone is the last intermediate common to both aclacinomycin and daunomycin biosynthesis aklavinone + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.362 Streptomyces sp. Q53882
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.362 7-oxodaunomycinone + NADPH + H+
-
 Streptomyces sp. daunomycinone + NADP+
-
 ?
1.1.1.362 aklaviketone + NADPH + H+ the enzyme is involved in the biosynthesis of the anthracyclins aclacinomycin and daunomycin. Aklavinone is the last intermediate common to both aclacinomycin and daunomycin biosynthesis Streptomyces sp. aklavinone + NADP+
-
 ?
1.1.1.362 aklaviketone + NADPH + H+ activity with NADH is 7% of the activity with NADPH Streptomyces sp. aklavinone + NADP+
-
 ?
1.1.1.362 maggiemycin + NADPH + H+
-
 Streptomyces sp. epsilon-rhodomycinone + NADP+
-
 ?

Subunits

EC Number Subunits Comment Organism
1.1.1.362 ? x * 25632, calculated from sequence Streptomyces sp.

Synonyms

EC Number Synonyms Comment Organism
1.1.1.362 DauE
-
 Streptomyces sp.

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.362 NADPH activity with NADH is 7% of the activity with NADPH Streptomyces sp.

General Information

EC Number General Information Comment Organism
1.1.1.362 physiological function the enzyme is involved in the biosynthesis of the anthracyclins aclacinomycin and daunomycin Streptomyces sp.