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Literature summary extracted from
- NMNAT suppresses tau-induced neurodegeneration by promoting clearance of hyperphosphorylated tau oligomers in a Drosophila model of tauopathy (2012), Hum. Mol. Genet., 21, 237-250.
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 2.7.7.1 | Drosophila melanogaster | - |
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- |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 2.7.7.1 | nicotinamide mononucleotide adenylyltransferase | - |
Drosophila melanogaster |
| 2.7.7.1 | NMNAT | - |
Drosophila melanogaster |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 2.7.7.1 | physiological function | the enzyme has both NAD synthase and chaperone function. The enzyme is essential for maintaining neuronal integrity under normal conditions and protects against several neurodegenerative conditions. Enzyme overexpression significantly suppresses both behavioral and morphological deficits associated with tauopathy by means of reducing the levels of hyperphosphorylated tau oligomers and rescueing age-dependent vacuolization induced by tau expression. The enzyme interacts with phosphorylated tau in vivo and promotes the ubiquitination and clearance of toxic tau species. Apoptosis activation is significantly reduced in brains overexpressing the enzyme, and neurodegeneration is suppressed | Drosophila melanogaster |
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