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Literature summary extracted from

  • Wang, Y.; Niemi, J.; Mäntsälä, P.
    Modification of aklavinone and aclacinomycins in vitro and in vivo by rhodomycin biosynthesis gene products (2002), FEMS Microbiol. Lett., 208, 117-122.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.13.180 aklavinone + NADPH + H+ + O2 Streptomyces purpurascens the enzyme is involved in the biosynthesis of the anthracycline antibiotic daunorubicin/doxorubicin pathway. During the biosynthesis of L-rhodomycins, RdmE first modifies aklavinone at C-11, and epsilon-rhodomycinone or aklavinone is subsequently glycosylated epsilon-rhodomycinone + NADP+ + H2O
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Organism

EC Number Organism UniProt Comment Textmining
1.14.13.180 Streptomyces purpurascens
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Purification (Commentary)

EC Number Purification (Comment) Organism
1.14.13.180
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Streptomyces purpurascens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.13.180 11-deoxy-beta-L-rhodomycinone + NADPH + H+ + O2 11-deoxy-L-rhodomycinone is a better substrate than aklavinone Streptomyces purpurascens beta-rhodomycinone + NADP+ + H2O
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1.14.13.180 aklavinone + NADPH + H+ + O2 the enzyme is involved in the biosynthesis of the anthracycline antibiotic daunorubicin/doxorubicin pathway. During the biosynthesis of L-rhodomycins, RdmE first modifies aklavinone at C-11, and epsilon-rhodomycinone or aklavinone is subsequently glycosylated Streptomyces purpurascens epsilon-rhodomycinone + NADP+ + H2O
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?
1.14.13.180 aklavinone + NADPH + H+ + O2 about 60% compared to the activity with 11-deoxy-L-rhodomycinone Streptomyces purpurascens epsilon-rhodomycinone + NADP+ + H2O
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1.14.13.180 additional information no activity with decarbomethoxyaklavinone or 15-demethoxyaklavinone Streptomyces purpurascens ?
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Synonyms

EC Number Synonyms Comment Organism
1.14.13.180 RdmE
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Streptomyces purpurascens

General Information

EC Number General Information Comment Organism
1.14.13.180 physiological function the enzyme is involved in the biosynthesis of the anthracycline antibiotic daunorubicin/doxorubicin pathway Streptomyces purpurascens