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Literature summary extracted from

  • Helgadottir, S.; Sinapah, S.; Soell, D.; Ling, J.
    Mutational analysis of Sep-tRNA:Cys-tRNA synthase reveals critical residues for tRNA-dependent cysteine formation (2012), FEBS Lett., 586, 60-63.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
2.5.1.73 C272S complete loss of activity Methanocaldococcus jannaschii
2.5.1.73 C64S complete loss of activity Methanocaldococcus jannaschii
2.5.1.73 C67S complete loss of activity Methanocaldococcus jannaschii
2.5.1.73 D182A 107% of wild-type activity Methanocaldococcus jannaschii
2.5.1.73 H126A complete loss of activity Methanocaldococcus jannaschii
2.5.1.73 H233A complete loss of activity Methanocaldococcus jannaschii
2.5.1.73 H325A 124% of wild-type activity Methanocaldococcus jannaschii
2.5.1.73 K234A complete loss of activity Methanocaldococcus jannaschii
2.5.1.73 K265A complete loss of activity Methanocaldococcus jannaschii
2.5.1.73 K354A/R356A 92% of wild-type activity Methanocaldococcus jannaschii
2.5.1.73 K370A 33% of wild-type activity Methanocaldococcus jannaschii
2.5.1.73 additional information active-site cysteine residues Cys39, Cys42 and Cys247 are essential for enzymic activity Methanocaldococcus jannaschii
2.5.1.73 N187A 85% of wild-type activity Methanocaldococcus jannaschii
2.5.1.73 N208A 101% of wild-type activity Methanocaldococcus jannaschii
2.5.1.73 R102A complete loss of activity Methanocaldococcus jannaschii
2.5.1.73 R292A 99% of wild-type activity Methanocaldococcus jannaschii
2.5.1.73 R96A 89% of wild-type activity Methanocaldococcus jannaschii
2.5.1.73 S231A complete loss of activity Methanocaldococcus jannaschii
2.5.1.73 Y127A 35% of wild-type activity Methanocaldococcus jannaschii

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.73 Methanocaldococcus jannaschii Q59072
-
-

Synonyms

EC Number Synonyms Comment Organism
2.5.1.73 SepCysS
-
 Methanocaldococcus jannaschii