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Literature summary extracted from

  • Zang, S.; Ali, Y.O.; Ruan, K.; Zhai, R.G.
    Nicotinamide mononucleotide adenylyltransferase maintains active zone structure by stabilizing Bruchpilot (2013), EMBO Rep., 14, 87-94.
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.1 Drosophila melanogaster
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.7.1 brain the enzyme localizes in photoreceptor and central brain synapses Drosophila melanogaster
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Synonyms

EC Number Synonyms Comment Organism
2.7.7.1 nicotinamide mononucleotide adenylyltransferase
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 Drosophila melanogaster
2.7.7.1 NMNAT
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 Drosophila melanogaster

General Information

EC Number General Information Comment Organism
2.7.7.1 malfunction enzyme loss results in ubiquitination, mislocalization and aggregation of the Bruchpilot protein, and subsequent active zone degeneration Drosophila melanogaster
2.7.7.1 physiological function the enzyme is required for maintaining active zone structural integrity in Drosophila by interacting with the active zone protein Bruchpilot and shielding it from activity-induced ubiquitin-proteasome-mediated degradation. The enzyme specifically maintains active zone structure by direct protein-protein interaction Drosophila melanogaster