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Literature summary extracted from

  • Spacilova, P.; Naus, P.; Pohl, R.; Votruba, I.; Snasel, J.; Zabranska, H.; Pichova, I.; Ameral, R.; Birkus, G.; Cihlar, T.; Hocek, M.
    CycloSal-phosphate pronucleotides of cytostatic 6-(Het)aryl-7-deazapurine ribonucleosides: Synthesis, cytostatic activity, and inhibition of adenosine kinases (2010), ChemMedChem, 5, 1386-1396.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.20 4-(1H-pyrazol-4-yl)-7-(beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine
-
 Homo sapiens
2.7.1.20 4-(1H-pyrazol-4-yl)-7-(beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine
-
 Mycobacterium tuberculosis
2.7.1.20 4-(furan-2-yl)-7-(beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine
-
 Homo sapiens
2.7.1.20 4-(furan-2-yl)-7-(beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine
-
 Mycobacterium tuberculosis
2.7.1.20 4-(furan-3-yl)-7-(beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine
-
 Homo sapiens
2.7.1.20 4-(furan-3-yl)-7-(beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine
-
 Mycobacterium tuberculosis
2.7.1.20 5-fluoro-4-(furan-2-yl)-7-(beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine
-
 Homo sapiens
2.7.1.20 5-fluoro-4-(furan-2-yl)-7-(beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine
-
 Mycobacterium tuberculosis
2.7.1.20 5-fluoro-4-(furan-3-yl)-7-(beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine
-
 Homo sapiens
2.7.1.20 5-fluoro-4-(furan-3-yl)-7-(beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine
-
 Mycobacterium tuberculosis
2.7.1.20 5-fluoro-7-(beta-D-ribofuranosyl)-4-(thiophen-2-yl)-7H-pyrrolo[2,3-d]pyrimidine
-
 Homo sapiens
2.7.1.20 5-fluoro-7-(beta-D-ribofuranosyl)-4-(thiophen-2-yl)-7H-pyrrolo[2,3-d]pyrimidine
-
 Mycobacterium tuberculosis
2.7.1.20 5-fluoro-7-(beta-D-ribofuranosyl)-4-(thiophen-3-yl)-7H-pyrrolo[2,3-d]pyrimidine
-
 Homo sapiens
2.7.1.20 5-fluoro-7-(beta-D-ribofuranosyl)-4-(thiophen-3-yl)-7H-pyrrolo[2,3-d]pyrimidine
-
 Mycobacterium tuberculosis
2.7.1.20 7-(beta-D-ribofuranosyl)-4-(1,3-thiazol-2-yl)-7H-pyrrolo[2,3-d]pyrimidine
-
 Homo sapiens
2.7.1.20 7-(beta-D-ribofuranosyl)-4-(1,3-thiazol-2-yl)-7H-pyrrolo[2,3-d]pyrimidine
-
 Mycobacterium tuberculosis
2.7.1.20 7-(beta-D-ribofuranosyl)-4-(thiophen-2-yl)-7H-pyrrolo[2,3-d]pyrimidine
-
 Homo sapiens
2.7.1.20 7-(beta-D-ribofuranosyl)-4-(thiophen-2-yl)-7H-pyrrolo[2,3-d]pyrimidine
-
 Mycobacterium tuberculosis
2.7.1.20 7-(beta-D-ribofuranosyl)-4-(thiophen-3-yl)-7H-pyrrolo[2,3-d]pyrimidine
-
 Homo sapiens
2.7.1.20 7-(beta-D-ribofuranosyl)-4-(thiophen-3-yl)-7H-pyrrolo[2,3-d]pyrimidine
-
 Mycobacterium tuberculosis
2.7.1.20 cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(2-benzofuryl)-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
-
 Homo sapiens
2.7.1.20 cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(2-benzofuryl)-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
-
 Mycobacterium tuberculosis
2.7.1.20 cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(2-furyl)-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
-
 Homo sapiens
2.7.1.20 cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(2-furyl)-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
-
 Mycobacterium tuberculosis
2.7.1.20 cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(2-furyl)-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
-
 Homo sapiens
2.7.1.20 cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(2-furyl)-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
-
 Mycobacterium tuberculosis
2.7.1.20 cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(2-thiazolyl)-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
-
 Homo sapiens
2.7.1.20 cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(2-thiazolyl)-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
-
 Mycobacterium tuberculosis
2.7.1.20 cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(2-thienyl)-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
-
 Homo sapiens
2.7.1.20 cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(2-thienyl)-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
-
 Mycobacterium tuberculosis
2.7.1.20 cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(2-thienyl)-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
-
 Homo sapiens
2.7.1.20 cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(2-thienyl)-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
-
 Mycobacterium tuberculosis
2.7.1.20 cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(3-furyl)-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
-
 Homo sapiens
2.7.1.20 cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(3-furyl)-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
-
 Mycobacterium tuberculosis
2.7.1.20 cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(3-furyl)-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
-
 Homo sapiens
2.7.1.20 cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(3-furyl)-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
-
 Mycobacterium tuberculosis
2.7.1.20 cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(3-thienyl)-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
-
 Homo sapiens
2.7.1.20 cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(3-thienyl)-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
-
 Mycobacterium tuberculosis
2.7.1.20 cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(3-thienyl)-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
-
 Homo sapiens
2.7.1.20 cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(3-thienyl)-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
-
 Mycobacterium tuberculosis
2.7.1.20 cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(4-dibenzofuryl)-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
-
 Homo sapiens
2.7.1.20 cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(4-dibenzofuryl)-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
-
 Mycobacterium tuberculosis
2.7.1.20 cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(4-pyrazolyl)-7 H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
-
 Homo sapiens
2.7.1.20 cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(4-pyrazolyl)-7 H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
-
 Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.20 Homo sapiens
-
-
-
2.7.1.20 Mycobacterium tuberculosis
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.20 CCRF-CEM cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.20 ATP + adenosine
-
 Homo sapiens ADP + AMP
-
 ?
2.7.1.20 ATP + adenosine
-
 Mycobacterium tuberculosis ADP + AMP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.20 ADK
-
 Homo sapiens
2.7.1.20 ADK
-
 Mycobacterium tuberculosis

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.7.1.20 0.000037
-
 in 50 mM HEPES (pH 6.2), 10 mM KCl, 1 mM MgCl2, temperature not specified in the publication Homo sapiens cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(2-benzofuryl)-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
2.7.1.20 0.000083
-
 in 50 mM HEPES (pH 6.2), 10 mM KCl, 1 mM MgCl2, temperature not specified in the publication Homo sapiens cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(2-thienyl)-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
2.7.1.20 0.00011
-
 in 50 mM HEPES (pH 6.2), 10 mM KCl, 1 mM MgCl2, temperature not specified in the publication Homo sapiens cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(2-furyl)-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
2.7.1.20 0.00029
-
 in 50 mM HEPES (pH 6.2), 10 mM KCl, 1 mM MgCl2, temperature not specified in the publication Homo sapiens cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(3-thienyl)-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
2.7.1.20 0.00032
-
 in 50 mM HEPES (pH 6.2), 10 mM KCl, 1 mM MgCl2, temperature not specified in the publication Homo sapiens cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(2-furyl)-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
2.7.1.20 0.00063
-
 in 50 mM HEPES (pH 6.2), 10 mM KCl, 1 mM MgCl2, temperature not specified in the publication Homo sapiens cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(2-thiazolyl)-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
2.7.1.20 0.00086
-
 in 50 mM HEPES (pH 6.2), 10 mM KCl, 1 mM MgCl2, temperature not specified in the publication Homo sapiens cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(2-thienyl)-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
2.7.1.20 0.00097
-
 in 50 mM HEPES (pH 6.2), 10 mM KCl, 1 mM MgCl2, temperature not specified in the publication Homo sapiens cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(3-thienyl)-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
2.7.1.20 0.0011
-
 in 50 mM HEPES (pH 6.2), 10 mM KCl, 1 mM MgCl2, temperature not specified in the publication Homo sapiens 5-fluoro-7-(beta-D-ribofuranosyl)-4-(thiophen-2-yl)-7H-pyrrolo[2,3-d]pyrimidine
2.7.1.20 0.0013
-
 in 50 mM HEPES (pH 6.2), 10 mM KCl, 1 mM MgCl2, temperature not specified in the publication Homo sapiens 4-(furan-2-yl)-7-(beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine
2.7.1.20 0.0013
-
 in 50 mM HEPES (pH 6.2), 10 mM KCl, 1 mM MgCl2, temperature not specified in the publication Homo sapiens 5-fluoro-4-(furan-2-yl)-7-(beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine
2.7.1.20 0.0014
-
 in 50 mM Tris-HCl (pH 8.0), 10 mM KCl, 10 mM MgCl2, temperature not specified in the publication Mycobacterium tuberculosis cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(2-benzofuryl)-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
2.7.1.20 0.0018
-
 in 50 mM HEPES (pH 6.2), 10 mM KCl, 1 mM MgCl2, temperature not specified in the publication Homo sapiens cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(4-dibenzofuryl)-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
2.7.1.20 0.002
-
 IC50 above 0.002 mM, in 50 mM HEPES (pH 6.2), 10 mM KCl, 1 mM MgCl2, temperature not specified in the publication Homo sapiens 7-(beta-D-ribofuranosyl)-4-(thiophen-2-yl)-7H-pyrrolo[2,3-d]pyrimidine
2.7.1.20 0.002
-
 in 50 mM Tris-HCl (pH 8.0), 10 mM KCl, 10 mM MgCl2, temperature not specified in the publication Mycobacterium tuberculosis cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(2-thiazolyl)-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
2.7.1.20 0.0024
-
 in 50 mM Tris-HCl (pH 8.0), 10 mM KCl, 10 mM MgCl2, temperature not specified in the publication Mycobacterium tuberculosis cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(2-thienyl)-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
2.7.1.20 0.0027
-
 in 50 mM HEPES (pH 6.2), 10 mM KCl, 1 mM MgCl2, temperature not specified in the publication Homo sapiens cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(3-furyl)-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
2.7.1.20 0.0031
-
 in 50 mM HEPES (pH 6.2), 10 mM KCl, 1 mM MgCl2, temperature not specified in the publication Homo sapiens cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(4-pyrazolyl)-7 H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
2.7.1.20 0.0036
-
 in 50 mM HEPES (pH 6.2), 10 mM KCl, 1 mM MgCl2, temperature not specified in the publication Homo sapiens cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(3-furyl)-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
2.7.1.20 0.0037
-
 in 50 mM Tris-HCl (pH 8.0), 10 mM KCl, 10 mM MgCl2, temperature not specified in the publication Mycobacterium tuberculosis cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(2-thienyl)-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
2.7.1.20 0.0037
-
 in 50 mM Tris-HCl (pH 8.0), 10 mM KCl, 10 mM MgCl2, temperature not specified in the publication Mycobacterium tuberculosis cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(3-thienyl)-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
2.7.1.20 0.0039
-
 in 50 mM Tris-HCl (pH 8.0), 10 mM KCl, 10 mM MgCl2, temperature not specified in the publication Mycobacterium tuberculosis cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(3-furyl)-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
2.7.1.20 0.004
-
 in 50 mM Tris-HCl (pH 8.0), 10 mM KCl, 10 mM MgCl2, temperature not specified in the publication Mycobacterium tuberculosis cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(3-thienyl)-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
2.7.1.20 0.004
-
 in 50 mM Tris-HCl (pH 8.0), 10 mM KCl, 10 mM MgCl2, temperature not specified in the publication Mycobacterium tuberculosis cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(2-furyl)-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
2.7.1.20 0.0047
-
 in 50 mM Tris-HCl (pH 8.0), 10 mM KCl, 10 mM MgCl2, temperature not specified in the publication Mycobacterium tuberculosis cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(2-furyl)-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
2.7.1.20 0.005
-
 IC50 above 0.005 mM, in 50 mM HEPES (pH 6.2), 10 mM KCl, 1 mM MgCl2, temperature not specified in the publication Homo sapiens 4-(1H-pyrazol-4-yl)-7-(beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine
2.7.1.20 0.005
-
 IC50 above 0.005 mM, in 50 mM HEPES (pH 6.2), 10 mM KCl, 1 mM MgCl2, temperature not specified in the publication Homo sapiens 7-(beta-D-ribofuranosyl)-4-(1,3-thiazol-2-yl)-7H-pyrrolo[2,3-d]pyrimidine
2.7.1.20 0.0065
-
 in 50 mM Tris-HCl (pH 8.0), 10 mM KCl, 10 mM MgCl2, temperature not specified in the publication Mycobacterium tuberculosis cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(4-dibenzofuryl)-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
2.7.1.20 0.008
-
 in 50 mM Tris-HCl (pH 8.0), 10 mM KCl, 10 mM MgCl2, temperature not specified in the publication Mycobacterium tuberculosis cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(3-furyl)-7H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate
2.7.1.20 0.01
-
 IC50 above 0.01 mM, in 50 mM HEPES (pH 6.2), 10 mM KCl, 1 mM MgCl2, temperature not specified in the publication Homo sapiens 4-(furan-3-yl)-7-(beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine
2.7.1.20 0.01
-
 IC50 above 0.01 mM, in 50 mM HEPES (pH 6.2), 10 mM KCl, 1 mM MgCl2, temperature not specified in the publication Homo sapiens 7-(beta-D-ribofuranosyl)-4-(thiophen-3-yl)-7H-pyrrolo[2,3-d]pyrimidine
2.7.1.20 0.01
-
 IC50 above 0.01 mM, in 50 mM HEPES (pH 6.2), 10 mM KCl, 1 mM MgCl2, temperature not specified in the publication Homo sapiens 5-fluoro-4-(furan-3-yl)-7-(beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine
2.7.1.20 0.01
-
 IC50 above 0.01 mM, in 50 mM HEPES (pH 6.2), 10 mM KCl, 1 mM MgCl2, temperature not specified in the publication Homo sapiens 5-fluoro-7-(beta-D-ribofuranosyl)-4-(thiophen-3-yl)-7H-pyrrolo[2,3-d]pyrimidine
2.7.1.20 0.025
-
 IC50 above 0.025 mM, in 50 mM Tris-HCl (pH 8.0), 10 mM KCl, 10 mM MgCl2, temperature not specified in the publication Mycobacterium tuberculosis cyclo-(3-methylsaligenyl)-beta-D-ribofuranosyl-4-(4-pyrazolyl)-7 H-pyrrolo[2,3-d]pyrimidine-5'-O-phosphate