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Literature summary extracted from

  • Sandercock, A.M.; Charles, E.H.; Scaife, W.; Kirkpatrick, P.N.; O’Brien, S.W.; Papageorgiou, E.A.; Spencer, J.B.; Williams, D.H.
    Biosynthesis of the di-meta-hydroxyphenylglycine constituent of the vancomycin-group antibiotic chloroeremomycin (2001), Chem. Commun. (Camb. ), 2001, 1252-12653.
No PubMed abstract available

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.6.1.103 expression of the N-terminal His6-tagged protein in Escherichia coli Amycolatopsis orientalis

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.6.1.103 49800
-
x * 49800, electrospray ionisation mass spectrometry Amycolatopsis orientalis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.6.1.103 (3,5-dihydroxyphenyl)(oxo)acetate + L-glutamate Amycolatopsis orientalis the enzyme is involved in the biosynthesis of (S)-3,5-dihydroxyphenylglycine constituent of the glycopeptide antibiotic chloroeremomycin (S)-3,5-dihydroxyphenylglycine + 2-oxoglutarate
-
?
2.6.1.103 (3,5-dihydroxyphenyl)(oxo)acetate + L-glutamate Amycolatopsis orientalis A82846 the enzyme is involved in the biosynthesis of (S)-3,5-dihydroxyphenylglycine constituent of the glycopeptide antibiotic chloroeremomycin (S)-3,5-dihydroxyphenylglycine + 2-oxoglutarate
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.103 Amycolatopsis orientalis
-
-
-
2.6.1.103 Amycolatopsis orientalis A82846
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.6.1.103
-
Amycolatopsis orientalis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.103 (3,5-dihydroxyphenyl)(oxo)acetate + L-glutamate the enzyme is involved in the biosynthesis of (S)-3,5-dihydroxyphenylglycine constituent of the glycopeptide antibiotic chloroeremomycin Amycolatopsis orientalis (S)-3,5-dihydroxyphenylglycine + 2-oxoglutarate
-
?
2.6.1.103 (3,5-dihydroxyphenyl)(oxo)acetate + L-glutamate the enzyme is involved in the biosynthesis of (S)-3,5-dihydroxyphenylglycine constituent of the glycopeptide antibiotic chloroeremomycin Amycolatopsis orientalis A82846 (S)-3,5-dihydroxyphenylglycine + 2-oxoglutarate
-
?
2.6.1.103 (S)-3,5-dihydroxyphenylglycine + 2-oxoglutarate
-
Amycolatopsis orientalis (3,5-dihydroxyphenyl)(oxo)acetate + L-glutamate
-
?
2.6.1.103 (S)-3,5-dihydroxyphenylglycine + 2-oxoglutarate
-
Amycolatopsis orientalis A82846 (3,5-dihydroxyphenyl)(oxo)acetate + L-glutamate
-
?

Subunits

EC Number Subunits Comment Organism
2.6.1.103 ? x * 49800, electrospray ionisation mass spectrometry Amycolatopsis orientalis

Synonyms

EC Number Synonyms Comment Organism
2.6.1.103 HpgT
-
Amycolatopsis orientalis

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.6.1.103 30
-
assay at Amycolatopsis orientalis

Cofactor

EC Number Cofactor Comment Organism Structure
2.6.1.103 pyridoxal 5'-phosphate a pyridoxal-phosphate protein Amycolatopsis orientalis

General Information

EC Number General Information Comment Organism
2.6.1.103 physiological function the enzyme is involved in the biosynthesis of (S)-3,5-dihydroxyphenylglycine of the glycopeptide antibiotic chloroeremomycin Amycolatopsis orientalis