EC Number | Application | Comment | Organism |
---|---|---|---|
2.7.1.71 | drug development | the enzyme is an attractive drug target as it is vital for the survival of Mycobacterium tuberculosis but absent in mammalian hosts | Mycobacterium tuberculosis |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.71 | asxe1 | - |
Mycobacterium tuberculosis | |
2.7.1.71 | additional information | screening for the dipeptide inhibitor using in silico structure-based design approach, docking analysis, overview | Mycobacterium tuberculosis |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.71 | Mg2+ | required | Mycobacterium tuberculosis |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.71 | ATP + shikimate | Mycobacterium tuberculosis | - |
ADP + 3-phosphoshikimate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.1.71 | Mycobacterium tuberculosis | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.71 | ATP + shikimate | - |
Mycobacterium tuberculosis | ADP + 3-phosphoshikimate | - |
? |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.71 | ATP | - |
Mycobacterium tuberculosis |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.1.71 | 0.000005 | - |
asxe1 | pH and temperature not specified in the publication | Mycobacterium tuberculosis |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.7.1.71 | additional information | shikimate binding to the enzyme, docking analysis, conformation of ternary dead-end enzyme-shikimate-ADP complex, molecular dynamics simulation of a fully hydrated model of the docked complex, overview | Mycobacterium tuberculosis |
2.7.1.71 | physiological function | shikimate kinase is vital for the survival of Mycobacterium tuberculosis | Mycobacterium tuberculosis |