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Literature summary extracted from

  • Krahmer, N.; Guo, Y.; Wilfling, F.; Hilger, M.; Lingrell, S.; Heger, K.; Newman, H.W.; Schmidt-Supprian, M.; Vance, D.E.; Mann, M.; Farese, R.V.; Walther, T.C.
    Phosphatidylcholine synthesis for lipid droplet expansion is mediated by localized activation of CTP:phosphocholine cytidylyltransferase (2011), Cell Metab., 14, 504-515.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.7.15 additional information binding to the lipid droplets activates the enzyme Drosophila melanogaster
2.7.7.15 additional information binding to the lipid droplets activates the enzyme Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.7.15 cytosol
-
 Drosophila melanogaster 5829
-
2.7.7.15 cytosol
-
 Mus musculus 5829
-
2.7.7.15 lipid droplet CTP:phosphocholine cytidylyltransferase binds stably and via its amphipatic alpha helix to lipid droplet surface during surface expansion, which is essential for the lipid droplet. It is the only enzyme of the phosphatidylecholine synthesis Kennedy pathway that localizes in the lipid droplets Drosophila melanogaster 5811
-
2.7.7.15 lipid droplet CTP:phosphocholine cytidylyltransferase binds stably and via its amphipatic alpha helix to lipid droplet surface during surface expansion, which is essential for the lipid droplet. It is the only enzyme of the phosphatidylecholine synthesis Kennedy pathway that localizes in the lipid droplets Mus musculus 5811
-
2.7.7.15 additional information CCT1 Is mobile and shuttles between nucleus and cytosol before oleate loading. CCT1 targets to lipid droplets after an initial delay and relocalizes to the nucleus when oleate is removed. CCT1 is targeted to lipid droplets when phosphatidylcholine levels are inadequate Drosophila melanogaster
-
-
2.7.7.15 additional information CCT1 Is mobile and shuttles between nucleus and cytosol before oleate loading. CCT1 targets to lipid droplets after an initial delay and relocalizes to the nucleus when oleate is removed. CCT1 is targeted to lipid droplets when phosphatidylcholine levels are inadequate Mus musculus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.15 CTP + phosphocholine Drosophila melanogaster
-
 diphosphate + CDP-choline
-
 ?
2.7.7.15 CTP + phosphocholine Mus musculus
-
 diphosphate + CDP-choline
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.15 Drosophila melanogaster
-
-
-
2.7.7.15 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.7.15 S2 cell
-
 Drosophila melanogaster
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.15 CTP + phosphocholine
-
 Drosophila melanogaster diphosphate + CDP-choline
-
 ?
2.7.7.15 CTP + phosphocholine
-
 Mus musculus diphosphate + CDP-choline
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.15 CCT
-
 Drosophila melanogaster
2.7.7.15 CCT
-
 Mus musculus
2.7.7.15 CCT1
-
 Drosophila melanogaster
2.7.7.15 CCT1
-
 Mus musculus
2.7.7.15 CTP:phosphocholine cytidylyltransferase
-
 Drosophila melanogaster
2.7.7.15 CTP:phosphocholine cytidylyltransferase
-
 Mus musculus

General Information

EC Number General Information Comment Organism
2.7.7.15 metabolism the enzyme catalyzes a step in the Kennedy pathway for phosphatidylecholine synthesis, overview Drosophila melanogaster
2.7.7.15 metabolism the enzyme catalyzes a step in the Kennedy pathway for phosphatidylecholine synthesis, overview Mus musculus
2.7.7.15 physiological function phosphatidylcholine acts as a surfactant to prevent lipid droplet coalescence, which otherwise yields large, lipolysis-resistant lipid droplets and triglyceride accumulation. The need for additional phosphatidylecholine to coat the enlarging surface during lipid droplet expansion is provided by the Kennedy pathway, which is activated by reversible targeting of the rate-limiting enzyme, CTP:phosphocholine cytidylyltransferase, to growing lipid droplet surfaces. CCT1 regulates lipid droplet size and triacylgylceride storage in vivo Drosophila melanogaster
2.7.7.15 physiological function phosphatidylcholine acts as a surfactant to prevent lipid droplet coalescence, which otherwise yields large, lipolysis-resistant lipid droplets and triglyceride accumulation. The need for additional phosphatidylecholine to coat the enlarging surface during lipid droplet expansion is provided by the Kennedy pathway, which is activated by reversible targeting of the rate-limiting enzyme, CTP:phosphocholine cytidylyltransferase, to growing lipid droplet surfaces. CCT1 regulates lipid droplet size and triacylgylceride storage in vivo Mus musculus