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Literature summary extracted from

  • Templin, A.T.; Maier, B.; Nishiki, Y.; Tersey, S.A.; Mirmira, R.G.
    Deoxyhypusine synthase haploinsufficiency attenuates acute cytokine signaling (2011), Cell Cycle, 10, 1043-1049.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.46 N1-guanyl-1,7-diaminoheptane i.e. GC7 Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.5.1.46 endoplasmic reticulum
-
 Mus musculus 5783
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.46 [eIF5A-precursor]-lysine + spermidine Mus musculus
-
 [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine
-
 ?
2.5.1.46 [eIF5A-precursor]-lysine + spermidine Mus musculus C57/BL6J
-
 [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.46 Mus musculus
-
-
-
2.5.1.46 Mus musculus C57/BL6J
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.5.1.46 fibroblast
-
 Mus musculus
-
2.5.1.46 liver
-
 Mus musculus
-
2.5.1.46 MEF cell
-
 Mus musculus
-
2.5.1.46 pancreatic beta cell
-
 Mus musculus
-
2.5.1.46 pancreatic islet beta-islet cell Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.46 [eIF5A-precursor]-lysine + spermidine
-
 Mus musculus [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine
-
 ?
2.5.1.46 [eIF5A-precursor]-lysine + spermidine
-
 Mus musculus C57/BL6J [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.46 DHS
-
 Mus musculus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.5.1.46 0.01
-
 N1-guanyl-1,7-diaminoheptane pH and temperature not specified in the publication Mus musculus

General Information

EC Number General Information Comment Organism
2.5.1.46 malfunction deoxyhypusine synthase haploinsufficiency attenuates acute cytokine signaling, overview. DHS dysfunction in the setting of diabetes mellitus, overview Mus musculus
2.5.1.46 additional information Dhps heterozygosity does not lead to significant inhibition of proliferation or cell cycle progression, Dhps heterozygosity does not alter growth or metabolic homeostasis, overview Mus musculus
2.5.1.46 physiological function deoxyhypusine synthase, DHS, catalyzes the post-translational formation of the amino acid hypusine. Hypusine is unique to the eukaryotic translational initiation factor 5A (eIF5A), and is required for its functions in mRNA shuttling, translational elongation and stress granule formation. DHS promotes cytokine and ER stress signaling in the islet beta cell and thereby contributes to its dysfunction in the setting of diabetes mellitus Mus musculus