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Literature summary extracted from

  • Lee, K.H.; Shim, M.S.; Kim, J.Y.; Jung, H.K.; Lee, E.; Carlson, B.A.; Xu, X.M.; Park, J.M.; Hatfield, D.L.; Park, T.; Lee, B.J.
    Drosophila selenophosphate synthetase 1 regulates vitamin B6 metabolism: prediction and confirmation (2011), BMC Genomics, 12, 426.
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
2.7.9.3 Drosophila melanogaster
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.9.3 SCHNEIDER-2 cell
-
 Drosophila melanogaster
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.9.3 ATP + selenide + H2O
-
 Drosophila melanogaster AMP + selenophosphate + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.9.3 selenophosphate synthetase 1
-
 Drosophila melanogaster
2.7.9.3 SPS 1
-
 Drosophila melanogaster

General Information

EC Number General Information Comment Organism
2.7.9.3 malfunction vitamin B6 biosynthesis is significantly affected at the early stage at which megamitochondria are not formed (day 3) after isoform SPS1 knockdown. Genes related to defense and amino acid metabolism are affected at a later stage (day 5) following enzyme knockdown. Levels of pyridoxal phosphate, an active form of vitamin B6, are decreased by isoform SPS1 knockdown Drosophila melanogaster
2.7.9.3 metabolism isoform selenophosphate synthetase 1 regulates vitamin B6 metabolism Drosophila melanogaster