EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.4.9 | 1-(((2R,3S,5S)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)methyl)-3-(((2S,3R,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)methyl)urea | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 2',5'-dideoxy-5'-(4-phenyl-1H-1,2,3-triazol-1-yl)-3,4-dihydrothymidine | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 2',5'-dideoxy-5'-([[3-(trifluoromethyl)phenyl]carbamoyl]amino)-3,4-dihydrothymidine | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 3',5'-diazido-2',3',5'-trideoxy-3,4-dihydrothymidine | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 3'-(4-chlorophenyl-1,2,3-triazol-1-yl)-3'-deoxy-4-thio-beta-D-thymidine | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 3'-(4-chlorophenyl-1,2,3-triazol-1-yl)-3'-deoxy-alpha-D-thymidine | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 3'-azido-3'-deoxy-4-thio-beta-D-thymidine | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 3'-azido-3'-deoxy-alpha-D-thymidine | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 3'-[([[4-chloro-3-(trifluoromethyl)phenyl]carbamothioyl]amino)methyl]-2',3'-dideoxy-3,4-dihydrothymidine | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 5'-(4-benzyl-1H-1,2,3-triazol-1-yl)-2',5'-dideoxy-3,4-dihydrothymidine | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 5'-(4-chlorophenyl-1,2,3-triazol-1-yl)-5'-deoxy-alpha-D-thymidine | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 5'-(4-chlorophenyl-1,2,3-triazol-1-yl)-5'-deoxy-beta-D-thymidine | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 5'-([[4-chloro-3-(trifluoromethyl)phenyl]carbamothioyl]amino)-2',5'-dideoxy-3,4-dihydro-alpha-thymidine | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 5'-([[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl]amino)-2',5'-dideoxy-3,4-dihydrothymidine | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 5'-azido-2',5'-dideoxy-3,4-dihydrothymidine | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 5'-[4-(4-chlorophenyl)-1H-1,2,3-triazol-1-yl]-2',5'-dideoxy-3,4-dihydrothymidine | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 5'-[5-(2-aminobenzyl)-1H-1,2,3-triazol-1-yl]-2',5'-dideoxy-3,4-dihydrothymidine | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 5'-[5-amino-4-[4-chloro-3-(trifluoromethyl)phenyl]-1H-1,2,3-triazol-1-yl]-2',5'-dideoxy-3,4-dihydrothymidine | - |
Mycobacterium tuberculosis | |
2.7.4.9 | 5-(5'-amino-5'-deoxy-beta-D-thymidin-5'-N-yl)-1-(4-chloro-3-trifluoromethylphenyl)-tetrazole | - |
Mycobacterium tuberculosis | |
2.7.4.9 | additional information | not inhibited by N-(5'-deoxy-4-thio-alpha-D-thymidin-5'-yl)-N'-phenylthiourea | Mycobacterium tuberculosis | |
2.7.4.9 | N-(5'-deoxy-4-thio-alpha-D-thymidin-5'-yl)-N'-(3-trifluoromethyl-4-chlorophenyl)thiourea | - |
Mycobacterium tuberculosis |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.4.9 | Mycobacterium tuberculosis | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.4.9 | ATP + dTMP | - |
Mycobacterium tuberculosis | ADP + dTDP | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.4.9 | thymidine monophosphate kinase | - |
Mycobacterium tuberculosis |
2.7.4.9 | TMPK | - |
Mycobacterium tuberculosis |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.4.9 | 0.00017 | - |
N-(5'-deoxy-4-thio-alpha-D-thymidin-5'-yl)-N'-(3-trifluoromethyl-4-chlorophenyl)thiourea | in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37°C | Mycobacterium tuberculosis | |
2.7.4.9 | 0.0006 | - |
5'-([[4-chloro-3-(trifluoromethyl)phenyl]carbamothioyl]amino)-2',5'-dideoxy-3,4-dihydro-alpha-thymidine | in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37°C | Mycobacterium tuberculosis | |
2.7.4.9 | 0.0021 | - |
5'-[4-(4-chlorophenyl)-1H-1,2,3-triazol-1-yl]-2',5'-dideoxy-3,4-dihydrothymidine | in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37°C | Mycobacterium tuberculosis | |
2.7.4.9 | 0.0023 | - |
5'-[5-(2-aminobenzyl)-1H-1,2,3-triazol-1-yl]-2',5'-dideoxy-3,4-dihydrothymidine | in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37°C | Mycobacterium tuberculosis | |
2.7.4.9 | 0.0027 | - |
5'-(4-benzyl-1H-1,2,3-triazol-1-yl)-2',5'-dideoxy-3,4-dihydrothymidine | in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37°C | Mycobacterium tuberculosis | |
2.7.4.9 | 0.0028 | - |
2',5'-dideoxy-5'-([[3-(trifluoromethyl)phenyl]carbamoyl]amino)-3,4-dihydrothymidine | in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37°C | Mycobacterium tuberculosis | |
2.7.4.9 | 0.0042 | - |
2',5'-dideoxy-5'-(4-phenyl-1H-1,2,3-triazol-1-yl)-3,4-dihydrothymidine | in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37°C | Mycobacterium tuberculosis | |
2.7.4.9 | 0.005 | - |
3'-[([[4-chloro-3-(trifluoromethyl)phenyl]carbamothioyl]amino)methyl]-2',3'-dideoxy-3,4-dihydrothymidine | in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37°C | Mycobacterium tuberculosis | |
2.7.4.9 | 0.006 | - |
3'-azido-3'-deoxy-alpha-D-thymidine | in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37°C | Mycobacterium tuberculosis | |
2.7.4.9 | 0.009 | - |
5'-(4-chlorophenyl-1,2,3-triazol-1-yl)-5'-deoxy-alpha-D-thymidine | in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37°C | Mycobacterium tuberculosis | |
2.7.4.9 | 0.0099 | - |
5'-([[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl]amino)-2',5'-dideoxy-3,4-dihydrothymidine | in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37°C | Mycobacterium tuberculosis | |
2.7.4.9 | 0.015 | - |
3'-(4-chlorophenyl-1,2,3-triazol-1-yl)-3'-deoxy-4-thio-beta-D-thymidine | in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37°C | Mycobacterium tuberculosis | |
2.7.4.9 | 0.0265 | - |
5'-azido-2',5'-dideoxy-3,4-dihydrothymidine | in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37°C | Mycobacterium tuberculosis | |
2.7.4.9 | 0.028 | - |
3',5'-diazido-2',3',5'-trideoxy-3,4-dihydrothymidine | in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37°C | Mycobacterium tuberculosis | |
2.7.4.9 | 0.035 | - |
3'-(4-chlorophenyl-1,2,3-triazol-1-yl)-3'-deoxy-alpha-D-thymidine | in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37°C | Mycobacterium tuberculosis | |
2.7.4.9 | 0.037 | - |
1-(((2R,3S,5S)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)methyl)-3-(((2S,3R,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)methyl)urea | in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37°C | Mycobacterium tuberculosis | |
2.7.4.9 | 0.045 | - |
5'-[5-amino-4-[4-chloro-3-(trifluoromethyl)phenyl]-1H-1,2,3-triazol-1-yl]-2',5'-dideoxy-3,4-dihydrothymidine | in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37°C | Mycobacterium tuberculosis | |
2.7.4.9 | 0.073 | - |
5-(5'-amino-5'-deoxy-beta-D-thymidin-5'-N-yl)-1-(4-chloro-3-trifluoromethylphenyl)-tetrazole | in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37°C | Mycobacterium tuberculosis | |
2.7.4.9 | 0.1 | - |
3'-azido-3'-deoxy-4-thio-beta-D-thymidine | Ki above 0.1 mM, in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37°C | Mycobacterium tuberculosis | |
2.7.4.9 | 0.201 | - |
5'-(4-chlorophenyl-1,2,3-triazol-1-yl)-5'-deoxy-beta-D-thymidine | in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37°C | Mycobacterium tuberculosis |