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Literature summary extracted from

  • De Schutter, J.; Zaretsky, S.; Welbourn, S.; Pause, A.; Tsantrizos, Y.
    Novel bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase (2010), Bioorg. Med. Chem. Lett., 20, 5781-5786.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.5.1.10 expressed in Escherichia coli Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.10 ([[6-(1-methyl-1H-pyrazol-4-yl)pyridin-3-yl]amino]methanediyl)bis(phosphonic acid)
-
Homo sapiens
2.5.1.10 ([[6-(3-methoxyphenyl)pyridin-3-yl]amino]methanediyl)bis(phosphonic acid)
-
Homo sapiens
2.5.1.10 ([[6-(thiophen-3-yl)pyridin-3-yl]amino]methanediyl)bis(phosphonic acid)
-
Homo sapiens
2.5.1.10 risedronate about 98% inhibition at 100 mM Homo sapiens
2.5.1.10 [([6-[3-(trifluoromethyl)phenyl]pyridin-3-yl]amino)methanediyl]bis(phosphonic acid)
-
Homo sapiens
2.5.1.10 [1-fluoro-2-[2-(1H-indazol-4-yl)pyridin-4-yl]ethane-1,1-diyl]bis(phosphonic acid)
-
Homo sapiens
2.5.1.10 [1-fluoro-2-[5-(1H-indazol-4-yl)pyridin-2-yl]ethane-1,1-diyl]bis(phosphonic acid)
-
Homo sapiens
2.5.1.10 [1-fluoro-2-[5-(1H-indazol-4-yl)pyridin-3-yl]ethane-1,1-diyl]bis(phosphonic acid)
-
Homo sapiens
2.5.1.10 [1-fluoro-2-[5-(1H-indazol-5-yl)pyridin-2-yl]ethane-1,1-diyl]bis(phosphonic acid)
-
Homo sapiens
2.5.1.10 [1-fluoro-2-[5-(1H-indazol-5-yl)pyridin-3-yl]ethane-1,1-diyl]bis(phosphonic acid)
-
Homo sapiens
2.5.1.10 [1-fluoro-2-[5-(1H-indazol-6-yl)pyridin-3-yl]ethane-1,1-diyl]bis(phosphonic acid)
-
Homo sapiens
2.5.1.10 [1-fluoro-2-[5-(1H-pyrazol-4-yl)pyridin-2-yl]ethane-1,1-diyl]bis(phosphonic acid)
-
Homo sapiens
2.5.1.10 [1-fluoro-2-[5-(1H-pyrazol-4-yl)pyridin-3-yl]ethane-1,1-diyl]bis(phosphonic acid)
-
Homo sapiens
2.5.1.10 [1-fluoro-2-[6-(1H-pyrazol-4-yl)pyridin-3-yl]ethane-1,1-diyl]bis(phosphonic acid)
-
Homo sapiens
2.5.1.10 [2-[2-(3,5-dimethyl-1,2-oxazol-4-yl)pyridin-4-yl]-1-fluoroethane-1,1-diyl]bis(phosphonic acid)
-
Homo sapiens
2.5.1.10 [2-[5-(3,5-dimethyl-1,2-oxazol-4-yl)pyridin-3-yl]-1-fluoroethane-1,1-diyl]bis(phosphonic acid)
-
Homo sapiens
2.5.1.10 [2-[6-(3,5-dimethyl-1,2-oxazol-4-yl)pyridin-2-yl]-1-fluoroethane-1,1-diyl]bis(phosphonic acid)
-
Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.10 Homo sapiens P14324
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.5.1.10 partial purification Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.10 geranyl diphosphate + isopentenyl diphosphate
-
Homo sapiens diphosphate + (2E,6E)-farnesyl diphosphate
-
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Synonyms

EC Number Synonyms Comment Organism
2.5.1.10 farnesyl pyrophosphate synthase
-
Homo sapiens
2.5.1.10 FPPS
-
Homo sapiens