EC Number | Cloned (Comment) | Organism |
---|---|---|
2.1.1.284 | expression in Escherichia coli | Streptomyces niveus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.1.1.284 | additional information | no substrate inhibition is observed at 2 mM S-adenosyl-L-methionine | Streptomyces niveus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.1.1.284 | 0.0265 | - |
8-demethylnovobiocic acid | pH 8.5, temperature not specified in the publication | Streptomyces niveus |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
2.1.1.284 | 26500 | - |
- |
Streptomyces niveus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.284 | S-adenosyl-L-methionine + 8-demethylnovobiocic acid | Streptomyces niveus | the enzyme is involved in the biosynthesis of the aminocoumarin antibiotic, novobiocin | S-adenosyl-L-homocysteine + novobiocic acid | - |
? | |
6.3.1.15 | ATP + 3-dimethylallyl-4-hydroxybenzoate + 3-amino-4,7-dihydroxycoumarin | Streptomyces niveus | the enzyme is involved in the biosynthesis of the aminocoumarin antibiotic novobiocin | AMP + diphosphate + 8-demethylnovobiocic acid | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.1.1.284 | Streptomyces niveus | - |
- |
- |
6.3.1.15 | Streptomyces niveus | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.1.1.284 | - |
Streptomyces niveus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.284 | S-adenosyl-L-methionine + 8-demethylnovobiocic acid | - |
Streptomyces niveus | S-adenosyl-L-homocysteine + novobiocic acid | - |
? | |
2.1.1.284 | S-adenosyl-L-methionine + 8-demethylnovobiocic acid | the enzyme is involved in the biosynthesis of the aminocoumarin antibiotic, novobiocin | Streptomyces niveus | S-adenosyl-L-homocysteine + novobiocic acid | - |
? | |
6.3.1.15 | ATP + 3-dimethylallyl-4-hydroxybenzoate + 3-amino-4,7-dihydroxycoumarin | - |
Streptomyces niveus | AMP + diphosphate + 8-demethylnovobiocic acid | - |
? | |
6.3.1.15 | ATP + 3-dimethylallyl-4-hydroxybenzoate + 3-amino-4,7-dihydroxycoumarin | the enzyme is involved in the biosynthesis of the aminocoumarin antibiotic novobiocin | Streptomyces niveus | AMP + diphosphate + 8-demethylnovobiocic acid | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.1.1.284 | NovO | - |
Streptomyces niveus |
6.3.1.15 | NovL | - |
Streptomyces niveus |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.1.1.284 | 0.5 | - |
8-demethylnovobiocic acid | pH 8.5, temperature not specified in the publication | Streptomyces niveus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.1.1.284 | 8.5 | - |
Tris-HCl buffer | Streptomyces niveus |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.1.1.284 | physiological function | the enzyme is involved in the biosynthesis of the aminocoumarin antibiotic, novobiocin | Streptomyces niveus |
6.3.1.15 | physiological function | the enzyme is involved in the biosynthesis of the aminocoumarin antibiotic novobiocin | Streptomyces niveus |