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Literature summary extracted from

  • Labes, A.; Schoenheit, P.
    Sugar utilization in the hyperthermophilic, sulfate-reducing archaeon Archaeoglobus fulgidus strain 7324: starch degradation to acetate and CO2 via a modified Embden-Meyerhof pathway and acetyl-CoA synthetase (ADP-forming) (2001), Arch. Microbiol., 176, 329-338.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.7.6 0.28
-
 D-glyceraldehyde 3-phosphate cosubstrate: benzyl viologen, 50°C, pH not specified in the publication Archaeoglobus fulgidus
2.7.1.40 0.6
-
 ADP 50°C, pH not specified in the publication Archaeoglobus fulgidus
2.7.1.40 3.3
-
 phosphoenolpyruvate 50°C, pH not specified in the publication Archaeoglobus fulgidus
2.7.1.146 1
-
 ADP 50°C, pH not specified in the publication Archaeoglobus fulgidus
2.7.1.146 3.3
-
 D-fructose 6-phosphate 50°C, pH not specified in the publication Archaeoglobus fulgidus
2.7.1.147 0.2
-
 ADP 50°C, pH not specified in the publication Archaeoglobus fulgidus
2.7.1.147 2.6
-
 D-glucose 50°C, pH not specified in the publication Archaeoglobus fulgidus
4.1.2.13 4.2
-
 D-fructose 1,6-bisphosphate 50°C, pH not specified in the publication Archaeoglobus fulgidus
4.2.1.11 2
-
 2-phospho-D-glycerate 50°C, pH not specified in the publication Archaeoglobus fulgidus
5.3.1.9 4
-
 D-fructose 6-phosphate 80°C, pH not specified in the publication Archaeoglobus fulgidus
6.2.1.13 0.015
-
 ADP 50°C, pH not specified in the publication Archaeoglobus fulgidus
6.2.1.13 0.023
-
 acetyl-CoA 50°C, pH not specified in the publication Archaeoglobus fulgidus
6.2.1.13 0.3
-
 phosphate 50°C, pH not specified in the publication Archaeoglobus fulgidus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.7.1 pyruvate + CoA + 2 oxidized ferredoxin Archaeoglobus fulgidus Archaeoglobus fulgidus strain 7324 converts starch to acetate via a modified Embden-Meyerhof pathway and acetyl-CoA synthetase (ADP-forming) acetyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+
-
 ?
1.2.7.6 D-glyceraldehyde 3-phosphate + H2O + 2 oxidized ferredoxin Archaeoglobus fulgidus the enzyme is involved in the modified Embden-Meyerhof pathway 3-phospho-D-glycerate + 2 H+ + 2 reduced ferredoxin
-
 ?
2.7.1.40 ADP + phosphoenolpyruvate Archaeoglobus fulgidus the enzyme is involved in the modified Embden-Meyerhof pathway ATP + pyruvate
-
 ?
2.7.1.146 ADP + D-fructose 6-phosphate Archaeoglobus fulgidus the enzyme is involved in the modified Embden-Meyerhof pathway AMP + D-fructose 1,6-bisphosphate
-
 ?
2.7.1.147 ADP + D-glucose Archaeoglobus fulgidus the enzyme is involved in the modified Embden-Meyerhof pathway AMP + D-glucose 6-phosphate
-
 ?
4.1.2.13 D-fructose 1,6-bisphosphate Archaeoglobus fulgidus the enzyme is involved in the modified Embden-Meyerhof pathway glycerone phosphate + D-glyceraldehyde 3-phosphate
-
 ?
4.1.2.13 D-fructose 1,6-bisphosphate Archaeoglobus fulgidus 7324 the enzyme is involved in the modified Embden-Meyerhof pathway glycerone phosphate + D-glyceraldehyde 3-phosphate
-
 ?
4.2.1.11 2-phospho-D-glycerate Archaeoglobus fulgidus the enzyme is involved in the modified Embden-Meyerhof pathway phosphoenolpyruvate + H2O
-
 ?
5.3.1.9 D-fructose 6-phosphate Archaeoglobus fulgidus the enzyme is involved in the modified Embden-Meyerhof pathway D-glucose 6-phosphate
-
 ?
5.3.1.9 D-fructose 6-phosphate Archaeoglobus fulgidus 7324 the enzyme is involved in the modified Embden-Meyerhof pathway D-glucose 6-phosphate
-
 ?
6.2.1.13 ADP + phosphate + acetyl-CoA Archaeoglobus fulgidus Archaeoglobus fulgidus strain 7324 converts starch to acetate via a modified Embden-Meyerhof pathway and acetyl-CoA synthetase (ADP-forming) ATP + acetate + CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.7.1 Archaeoglobus fulgidus
-
-
-
1.2.7.1 Archaeoglobus fulgidus 7324
-
-
-
1.2.7.6 Archaeoglobus fulgidus
-
-
-
1.2.7.6 Archaeoglobus fulgidus 7324
-
-
-
2.7.1.40 Archaeoglobus fulgidus
-
-
-
2.7.1.40 Archaeoglobus fulgidus 7324
-
-
-
2.7.1.146 Archaeoglobus fulgidus
-
-
-
2.7.1.146 Archaeoglobus fulgidus 7324
-
-
-
2.7.1.147 Archaeoglobus fulgidus
-
-
-
2.7.1.147 Archaeoglobus fulgidus 7324
-
-
-
4.1.2.13 Archaeoglobus fulgidus
-
-
-
4.1.2.13 Archaeoglobus fulgidus 7324
-
-
-
4.2.1.11 Archaeoglobus fulgidus
-
-
-
4.2.1.11 Archaeoglobus fulgidus 7324
-
-
-
5.3.1.9 Archaeoglobus fulgidus
-
-
-
5.3.1.9 Archaeoglobus fulgidus 7324
-
-
-
6.2.1.13 Archaeoglobus fulgidus
-
-
-
6.2.1.13 Archaeoglobus fulgidus 7324
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.7.1 culture condition:starch-grown cell
-
 Archaeoglobus fulgidus
-
1.2.7.6 culture condition:starch-grown cell specific activity is 10fold higher in starch-grown cells than in lactate-grown cells Archaeoglobus fulgidus
-
2.7.1.40 culture condition:D-lactate-grown cell specific activity is 5fold higher in starch-grown cells than in lactate-grown cells Archaeoglobus fulgidus
-
2.7.1.40 culture condition:starch-grown cell specific activity is 5fold higher in starch-grown cells than in lactate-grown cells Archaeoglobus fulgidus
-
2.7.1.146 culture condition:D-lactate-grown cell specific activity is 11fold higher in starch-grown cells than in lactate-grown cells Archaeoglobus fulgidus
-
2.7.1.146 culture condition:starch-grown cell specific activity is 11fold higher in starch-grown cells than in lactate-grown cells Archaeoglobus fulgidus
-
2.7.1.147 culture condition:D-lactate-grown cell specific activity is 14fold higher in starch-grown cells than in lactate-grown cells Archaeoglobus fulgidus
-
2.7.1.147 culture condition:starch-grown cell specific activity is 14fold higher in starch-grown cells than in lactate-grown cells Archaeoglobus fulgidus
-
4.1.2.13 culture condition:starch-grown cell
-
 Archaeoglobus fulgidus
-
4.2.1.11 culture condition:starch-grown cell
-
 Archaeoglobus fulgidus
-
5.3.1.9 culture condition:D-lactate-grown cell
-
 Archaeoglobus fulgidus
-
5.3.1.9 culture condition:starch-grown cell
-
 Archaeoglobus fulgidus
-
6.2.1.13 culture condition:D-lactate-grown cell specific activity is 10fold higher in starch-grown cells than in lactate-grown cells Archaeoglobus fulgidus
-
6.2.1.13 culture condition:starch-grown cell specific activity is 10fold higher in starch-grown cells than in lactate-grown cells Archaeoglobus fulgidus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.2.7.1 0.13
-
 50°C, pH not specified in the publication, enzyme from lactate-grown cells Archaeoglobus fulgidus
1.2.7.6 0.07
-
 substrate: D-glyceraldehyde 3-phosphate (cosubstrate: benzyl viologen), 50°C, pH not specified in the publication, enzyme from starch-grown cells Archaeoglobus fulgidus
2.7.1.40 0.028
-
 50°C, pH not specified in the publication, enzyme from lactate-grown cells Archaeoglobus fulgidus
2.7.1.40 0.13
-
 50°C, pH not specified in the publication, enzyme from starch-grown cells Archaeoglobus fulgidus
2.7.1.146 0.01
-
 substrate: D-fructose 6-phosphate, 50°C, pH not specified in the publication, enzyme from lactate-grown cells Archaeoglobus fulgidus
2.7.1.146 0.11
-
 substrate: D-fructose 6-phosphate, 50°C, pH not specified in the publication, enzyme from starch-grown cells Archaeoglobus fulgidus
2.7.1.147 0.007
-
 substrate: D-glucose, 50°C, pH not specified in the publication, enzyme from lactate-grown cells Archaeoglobus fulgidus
2.7.1.147 0.1
-
 substrate: D-glucose, 50°C, pH not specified in the publication, enzyme from starch-grown cells Archaeoglobus fulgidus
4.1.2.13 0.01
-
 substrate: D-fructose 1,6-bisphosphate, 50°C, pH not specified in the publication, enzyme from starch-grown cells Archaeoglobus fulgidus
4.2.1.11 0.79
-
 substrate: 2-phospho-D-glycerate, 50°C, pH not specified in the publication, enzyme from starch-grown cells Archaeoglobus fulgidus
5.3.1.9 0.06
-
 substrate: D-fructose 6-phosphate, 80°C, pH not specified in the publication Archaeoglobus fulgidus
6.2.1.13 0.03
-
 50°C, pH not specified in the publication, enzyme from starch-grown cells Archaeoglobus fulgidus
6.2.1.13 0.3
-
 50°C, pH not specified in the publication, enzyme from lactate-grown cells Archaeoglobus fulgidus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.7.1 pyruvate + CoA + 2 oxidized ferredoxin Archaeoglobus fulgidus strain 7324 converts starch to acetate via a modified Embden-Meyerhof pathway and acetyl-CoA synthetase (ADP-forming) Archaeoglobus fulgidus acetyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+
-
 ?
1.2.7.1 pyruvate + CoA + benzyl viologen
-
 Archaeoglobus fulgidus acetyl-CoA + CO2 + reduced benzyl viologen
-
 ?
1.2.7.6 D-glyceraldehyde 3-phosphate + H2O + 2 oxidized ferredoxin
-
 Archaeoglobus fulgidus 3-phospho-D-glycerate + 2 H+ + 2 reduced ferredoxin
-
 ?
1.2.7.6 D-glyceraldehyde 3-phosphate + H2O + 2 oxidized ferredoxin the enzyme is involved in the modified Embden-Meyerhof pathway Archaeoglobus fulgidus 3-phospho-D-glycerate + 2 H+ + 2 reduced ferredoxin
-
 ?
1.2.7.6 D-glyceraldehyde 3-phosphate + H2O + oxidized benzyl viologen
-
 Archaeoglobus fulgidus 3-phospho-D-glycerate + H+ + reduced benzyl viologen
-
 ?
2.7.1.40 ADP + phosphoenolpyruvate
-
 Archaeoglobus fulgidus ATP + pyruvate
-
 ?
2.7.1.40 ADP + phosphoenolpyruvate the enzyme is involved in the modified Embden-Meyerhof pathway Archaeoglobus fulgidus ATP + pyruvate
-
 ?
2.7.1.146 ADP + D-fructose 6-phosphate the enzyme is involved in the modified Embden-Meyerhof pathway Archaeoglobus fulgidus AMP + D-fructose 1,6-bisphosphate
-
 ?
2.7.1.146 ADP + D-fructose 6-phosphate diphosphate and ATP do not serve as phosphoryl donors Archaeoglobus fulgidus AMP + D-fructose 1,6-bisphosphate
-
 ?
2.7.1.147 ADP + D-glucose the enzyme is involved in the modified Embden-Meyerhof pathway Archaeoglobus fulgidus AMP + D-glucose 6-phosphate
-
 ?
2.7.1.147 ADP + D-glucose diphosphate and ATP do not serve as phosphoryl donor Archaeoglobus fulgidus AMP + D-glucose 6-phosphate
-
 ?
4.1.2.13 D-fructose 1,6-bisphosphate
-
 Archaeoglobus fulgidus glycerone phosphate + D-glyceraldehyde 3-phosphate
-
 ?
4.1.2.13 D-fructose 1,6-bisphosphate the enzyme is involved in the modified Embden-Meyerhof pathway Archaeoglobus fulgidus glycerone phosphate + D-glyceraldehyde 3-phosphate
-
 ?
4.1.2.13 D-fructose 1,6-bisphosphate
-
 Archaeoglobus fulgidus 7324 glycerone phosphate + D-glyceraldehyde 3-phosphate
-
 ?
4.1.2.13 D-fructose 1,6-bisphosphate the enzyme is involved in the modified Embden-Meyerhof pathway Archaeoglobus fulgidus 7324 glycerone phosphate + D-glyceraldehyde 3-phosphate
-
 ?
4.2.1.11 2-phospho-D-glycerate
-
 Archaeoglobus fulgidus phosphoenolpyruvate + H2O
-
 ?
4.2.1.11 2-phospho-D-glycerate the enzyme is involved in the modified Embden-Meyerhof pathway Archaeoglobus fulgidus phosphoenolpyruvate + H2O
-
 ?
5.3.1.9 D-fructose 6-phosphate
-
 Archaeoglobus fulgidus D-glucose 6-phosphate
-
 ?
5.3.1.9 D-fructose 6-phosphate the enzyme is involved in the modified Embden-Meyerhof pathway Archaeoglobus fulgidus D-glucose 6-phosphate
-
 ?
5.3.1.9 D-fructose 6-phosphate
-
 Archaeoglobus fulgidus 7324 D-glucose 6-phosphate
-
 ?
5.3.1.9 D-fructose 6-phosphate the enzyme is involved in the modified Embden-Meyerhof pathway Archaeoglobus fulgidus 7324 D-glucose 6-phosphate
-
 ?
6.2.1.13 ADP + phosphate + acetyl-CoA
-
 Archaeoglobus fulgidus ATP + acetate + CoA
-
 ?
6.2.1.13 ADP + phosphate + acetyl-CoA Archaeoglobus fulgidus strain 7324 converts starch to acetate via a modified Embden-Meyerhof pathway and acetyl-CoA synthetase (ADP-forming) Archaeoglobus fulgidus ATP + acetate + CoA
-
 ?
6.2.1.13 ADP + phosphate + acetyl-CoA
-
 Archaeoglobus fulgidus 7324 ATP + acetate + CoA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.2.7.1 pyruvate:ferredoxin oxidoreductase
-
 Archaeoglobus fulgidus
1.2.7.6 GAP:FdOR
-
 Archaeoglobus fulgidus
1.2.7.6 glyceraldehyde-3-phosphate:Fd-OR
-
 Archaeoglobus fulgidus
1.2.7.6 glyceraldehyde-3-phosphate:ferredoxin oxidoreductase
-
 Archaeoglobus fulgidus
2.7.1.146 ADP-dependent 6-phosphofructokinase
-
 Archaeoglobus fulgidus
2.7.1.146 ADP-Pfk
-
 Archaeoglobus fulgidus
2.7.1.147 ADP-dependent hexokinase
-
 Archaeoglobus fulgidus
2.7.1.147 ADP-HK
-
 Archaeoglobus fulgidus
5.3.1.9 glucose-6-phosphate isomerase
-
 Archaeoglobus fulgidus
5.3.1.9 Phosphoglucose isomerase
-
 Archaeoglobus fulgidus
6.2.1.13 ADP-ACS
-
 Archaeoglobus fulgidus
6.2.1.13 ADP-forming acetyl-CoA synthetase
-
 Archaeoglobus fulgidus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.2.7.1 50
-
 assay at Archaeoglobus fulgidus
1.2.7.6 50
-
 assay at Archaeoglobus fulgidus
2.7.1.40 50
-
 assay at Archaeoglobus fulgidus
2.7.1.146 50
-
 assay at Archaeoglobus fulgidus
2.7.1.147 50
-
 assay at Archaeoglobus fulgidus
4.1.2.13 50
-
 assay at Archaeoglobus fulgidus
4.2.1.11 50
-
 assay at Archaeoglobus fulgidus
5.3.1.9 80
-
 assay at Archaeoglobus fulgidus
6.2.1.13 50
-
 assay at Archaeoglobus fulgidus

General Information

EC Number General Information Comment Organism
1.2.7.1 physiological function Archaeoglobus fulgidus strain 7324 converts starch to acetate via a modified Embden-Meyerhof pathway and acetyl-CoA synthetase (ADP-forming) Archaeoglobus fulgidus
1.2.7.6 physiological function the enzyme is involved in the modified Embden-Meyerhof pathway Archaeoglobus fulgidus
2.7.1.40 physiological function the enzyme is involved in the modified Embden-Meyerhof pathway Archaeoglobus fulgidus
2.7.1.146 physiological function the enzyme is involved in the modified Embden-Meyerhof pathway Archaeoglobus fulgidus
2.7.1.147 physiological function the enzyme is involved in the modified Embden-Meyerhof pathway Archaeoglobus fulgidus
4.1.2.13 physiological function the enzyme is involved in the modified Embden-Meyerhof pathway Archaeoglobus fulgidus
4.2.1.11 physiological function the enzyme is involved in the modified Embden-Meyerhof pathway Archaeoglobus fulgidus
5.3.1.9 physiological function the enzyme is involved in the modified Embden-Meyerhof pathway Archaeoglobus fulgidus
6.2.1.13 physiological function Archaeoglobus fulgidus strain 7324 converts starch to acetate via a modified Embden-Meyerhof pathway and acetyl-CoA synthetase (ADP-forming) Archaeoglobus fulgidus