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Literature summary extracted from

  • Azevedo, C.; Szijgyarto, Z.; Saiardi, A.
    The signaling role of inositol hexakisphosphate kinases (IP6Ks) (2011), Adv. Enzyme Regul., 51, 74-82.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.4.21 H2O2 H2O2 as low as 0.1 mM dramatically reduces enzymatic activity Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.4.21 1.4
-
 ATP pH and temperature not specified in the publication Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.7.4.21 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.4.21 brain
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.4.21 ATP + 1D-myo-inositol hexakisphosphate
-
 Rattus norvegicus ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)-pentakisphosphate
-
 ?
2.7.4.21 additional information isoforms IP6K1 and IP6K2 bind to AP3B1protein Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.4.21 inositol hexakisphosphate kinase
-
 Rattus norvegicus
2.7.4.21 IP6K
-
 Rattus norvegicus
2.7.4.21 IP6K1 isoform Rattus norvegicus
2.7.4.21 IP6K2 isoform Rattus norvegicus
2.7.4.21 IP6K3 isoform Rattus norvegicus

General Information

EC Number General Information Comment Organism
2.7.4.21 malfunction deletion of isoform IP6K2 prevents the apoptotic actions of interferon beta and gamma-irradiation and cisplatin in different cancer cell lines Rattus norvegicus
2.7.4.21 physiological function isoform IP6K2 plays a specific role in regulating cell death. Isoform IP6K2 overexpression, that causes 10 to 20fold increase in IP7 level, enhances cell death Rattus norvegicus