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Literature summary extracted from

  • Clarke, J.; Irvine, R.
    The activity, evolution and association of phosphatidylinositol 5-phosphate 4-kinases (2012), Adv. Biol. Regul., 52, 40-45.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.149 PI5P4Kalpha is predominantly in the cytoplasm, principally cytosolic, when recombinantly expressed Mammalia

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.149 cytosol recombinantly expressed PI5P4Kalpha Mammalia 5829
-
2.7.1.149 membrane PI5P4Kalpha is membrane-bound in DT40 cells with a significant amount of endogenous PI5P4Kalpha in the nucleus Mammalia 16020
-
2.7.1.149 additional information analysis of subcellular localization of native and recombinant isozyme PI5P4Kalpha, overview Mammalia
-
-
2.7.1.149 nucleus PI5P4Kalpha is membrane-bound in DT40 cells with a significant amount of endogenous PI5P4Kalpha in the nucleus Mammalia 5634
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.149 Mg2+ required Mammalia

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.149 ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate Mammalia
-
 ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.149 Mammalia
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.149 DT-40 cell
-
 Mammalia
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.149 ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate
-
 Mammalia ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.149 phosphatidylinositol 5-phosphate 4-kinase
-
 Mammalia
2.7.1.149 PI5P4K
-
 Mammalia
2.7.1.149 PI5P4Kalpha
-
 Mammalia

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.149 ATP
-
 Mammalia

General Information

EC Number General Information Comment Organism
2.7.1.149 evolution PI5P4Kalpha is present in all vertebrates, and a few organisms are missing either beta or gamma. Several key structural differences between the three mammalian PI5P4Ks largely account for their different activities, e.g. a glycine-rich loop supposed to be involved with substrate interaction Mammalia