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Literature summary extracted from

  • Wrenger, C.; Mueller, I.B.; Butzloff, S.; Jordanova, R.; Lunev, S.; Groves, M.R.
    Crystallization and preliminary X-ray diffraction of malate dehydrogenase from Plasmodium falciparum (2012), Acta Crystallogr. Sect. F, 68, 659-662.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.37 gene YlMDH1 Yarrowia lipolytica
1.1.1.37 gene YlMDH2, subject for alternative splicing, DNA and amino acid sequence determination and analysis, phylogenetic analysis, construction and generation of three different splicing variants of YlMDH2 and transcriptional regulation analysis, overview Yarrowia lipolytica

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.37 cytosol gene YlMDH2 encodes the cytosolic and peroxisomal forms of MDH Yarrowia lipolytica 5829
-
1.1.1.37 mitochondrion
-
 Yarrowia lipolytica 5739
-
1.1.1.37 peroxisome gene YlMDH2 encodes the cytosolic and peroxisomal forms of MDH Yarrowia lipolytica 5777
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.37 (S)-malate + NAD+ Yarrowia lipolytica
-
 oxaloacetate + NADH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.37 Yarrowia lipolytica Q6C5X9 gene YlMDH2; several strains, overview, gene YALI0E14190g or YlMDH2
-
1.1.1.37 Yarrowia lipolytica Q6C8V3 isozyme YlMDH1; gene YALI0D16753g or YlMDH1
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.37 (S)-malate + NAD+
-
 Yarrowia lipolytica oxaloacetate + NADH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.37 YlMdh2p
-
 Yarrowia lipolytica

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.37 NAD+
-
 Yarrowia lipolytica

General Information

EC Number General Information Comment Organism
1.1.1.37 evolution the three different enzyme forms in cytosol, peroxisome and mitochondrion are encoded by three different genes in Saccharomyces cerevisiae, but by only two genes in Yarrowia lipolytica, where the second gene is differentiated into cytosolic and peroxisomal isozymes by alternative splicing, overview Yarrowia lipolytica
1.1.1.37 malfunction absence of either the peroxisomal or the cytosolic form of the MDH does not affect growth rate, irrespective of the carbon source Yarrowia lipolytica
1.1.1.37 additional information possible role for alternative splicing in the regulation of MDH compartmentalization in this yeast, gene YlMDH2 encodes the cytosolic and peroxisomal forms of MDH Yarrowia lipolytica