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Literature summary extracted from

  • Castell, A.; Mille, C.; Unge, T.
    Structural analysis of mycobacterial branched-chain aminotransferase: implications for inhibitor design (2010), Acta Crystallogr. Sect. D, 66, 549-557.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.6.1.42 His-tagged protein expressed in Escherichia coli BL21AI Mycobacterium tuberculosis
2.6.1.42 His-tagged protein expressed in Escherichia coli BL21AI Mycolicibacterium smegmatis

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.6.1.42 hanging drop method, ammonium sulfate, PEG 3350 Mycolicibacterium smegmatis

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.6.1.42 NH4+
-
Mycobacterium tuberculosis
2.6.1.42 O-Benzylhydroxylamine
-
Mycobacterium tuberculosis
2.6.1.42 O-Benzylhydroxylamine
-
Mycolicibacterium smegmatis

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.42 Mycobacterium tuberculosis
-
-
-
2.6.1.42 Mycolicibacterium smegmatis A0R066
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.6.1.42 immobilized metal ion affinity chromatography (Ni2+), gel filtration Mycobacterium tuberculosis
2.6.1.42 immobilized metal ion affinity chromatography (Ni2+), gel filtration Mycolicibacterium smegmatis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.42 L-isoleucine + 2-oxoglutarate
-
Mycobacterium tuberculosis 3-methyl-2-oxopentanoic acid + L-glutamate
-
r
2.6.1.42 L-isoleucine + 2-oxoglutarate
-
Mycolicibacterium smegmatis 3-methyl-2-oxopentanoic acid + L-glutamate
-
r
2.6.1.42 L-leucine + 2-oxoglutarate
-
Mycobacterium tuberculosis 4-methyl-2-oxopentanoic acid + L-glutamate
-
r
2.6.1.42 L-leucine + 2-oxoglutarate
-
Mycolicibacterium smegmatis 4-methyl-2-oxopentanoic acid + L-glutamate
-
r
2.6.1.42 L-valine + 2-oxoglutarate
-
Mycobacterium tuberculosis 3-methyl-2-oxobutanoic acid + L-glutamate
-
r
2.6.1.42 L-valine + 2-oxoglutarate
-
Mycolicibacterium smegmatis 3-methyl-2-oxobutanoic acid + L-glutamate
-
r

Subunits

EC Number Subunits Comment Organism
2.6.1.42 homodimer
-
Mycobacterium tuberculosis
2.6.1.42 homodimer
-
Mycolicibacterium smegmatis

Synonyms

EC Number Synonyms Comment Organism
2.6.1.42 branched-chain aminotransferase
-
Mycobacterium tuberculosis
2.6.1.42 branched-chain aminotransferase
-
Mycolicibacterium smegmatis

Cofactor

EC Number Cofactor Comment Organism Structure
2.6.1.42 pyridoxal 5'-phosphate
-
Mycobacterium tuberculosis
2.6.1.42 pyridoxal 5'-phosphate
-
Mycolicibacterium smegmatis

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.6.1.42 0.01
-
pH 7.5, 37°C Mycobacterium tuberculosis NH4+
2.6.1.42 0.042
-
pH 7.5, 37°C Mycolicibacterium smegmatis O-Benzylhydroxylamine
2.6.1.42 0.065
-
pH 7.5, 37°C Mycobacterium tuberculosis O-Benzylhydroxylamine