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Literature summary extracted from

  • Kita, S.; Tanaka, Y.; Hirano, N.; Kimura, S.; Suzuki, T.; Suzuki, T.; Yao, M.; Tanaka, I.
    Crystal structure of a putative methyltransferase SAV1081 from Staphylococcus aureus (2013), Protein Pept. Lett., 20, 530-537.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.1.173 expressed in Staphylococcus aureus Escherichia coli

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.1.1.264 crystal structure analysis, overview Staphylococcus aureus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.173 S-adenosyl-L-methionine + guanine2445 in 23S rRNA Escherichia coli
-
 S-adenosyl-L-homocysteine + N2-methylguanine2445 in 23S rRNA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.173 Escherichia coli P75864
-
-
2.1.1.191 no activity in Staphylococcus aureus
-
-
-
2.1.1.264 Staphylococcus aureus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.173 S-adenosyl-L-methionine + guanine2445 in 23S rRNA
-
 Escherichia coli S-adenosyl-L-homocysteine + N2-methylguanine2445 in 23S rRNA
-
 ?
2.1.1.264 additional information the enzyme also catalyzes the N2-methylation of guanine2445 in 23S rRNA, reaction of EC 2.1.1.173 Staphylococcus aureus ?
-
 ?
2.1.1.264 S-adenosyl-L-methionine + guanine2069 in 23S rRNA
-
 Staphylococcus aureus S-adenosyl-L-homocysteine + N7-methylguanine2069 in 23S rRNA
-
 ?

Subunits

EC Number Subunits Comment Organism
2.1.1.264 More domain organization, overview Staphylococcus aureus

Synonyms

EC Number Synonyms Comment Organism
2.1.1.173 ycbY
-
 Escherichia coli
2.1.1.264 SAV1081
-
 Staphylococcus aureus

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.1.264 S-adenosyl-L-methionine
-
 Staphylococcus aureus

General Information

EC Number General Information Comment Organism
2.1.1.264 evolution SAV1081 belongs to te cluster of orthologous groups (COG) 1092, functional classification, overview Staphylococcus aureus