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Literature summary extracted from

  • Tsai, C.S.; Winans, S.C.
    LuxR-type quorum-sensing regulators that are detached from common scents (2010), Mol. Microbiol., 77, 1072-1082.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.184 gene expI, is transcribed convergently and overlapping at their 3' ends with gene expR Dickeya chrysanthemi

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.184 3-oxo-octanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine Agrobacterium tumefaciens TraI synthesizes primarily 3-oxo-octanoyl homoserine lactone [acyl-carrier protein] + S-methyl-5'-thioadenosine + 3-oxo-octanoyl-L-homoserine lactone
-
 ?
2.3.1.184 3-oxododecanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine Pseudomonas aeruginosa LasI [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxododecanoyl-L-homoserine lactone
-
 ?
2.3.1.184 3-oxohexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine Aliivibrio fischeri
-
 [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxohexanoyl-L-homoserine lactone
-
 ?
2.3.1.184 3-oxohexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine Yersinia pseudotuberculosis
-
 [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxohexanoyl-L-homoserine lactone
-
 ?
2.3.1.184 3-oxohexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine Dickeya chrysanthemi
-
 [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxohexanoyl-L-homoserine lactone
-
 ?
2.3.1.184 3-oxohexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine Pectobacterium carotovorum
-
 [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxohexanoyl-L-homoserine lactone
-
 ?
2.3.1.184 3-oxohexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine Yersinia pestis
-
 [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxohexanoyl-L-homoserine lactone
-
 ?
2.3.1.184 3-oxohexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine Pseudomonas syringae
-
 [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxohexanoyl-L-homoserine lactone
-
 ?
2.3.1.184 3-oxohexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine Yersinia enterocolitica
-
 [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxohexanoyl-L-homoserine lactone
-
 ?
2.3.1.184 3-oxohexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine Pantoea stewartii
-
 [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxohexanoyl-L-homoserine lactone
-
 ?
2.3.1.184 3-oxohexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine Serratia marcescens SpnI (like EsaI) synthesizes primarily N-3-oxohexanoyl-L-homoserine lactone [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxohexanoyl-L-homoserine lactone
-
 ?
2.3.1.184 3-oxohexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine Serratia marcescens SS-1 SpnI (like EsaI) synthesizes primarily N-3-oxohexanoyl-L-homoserine lactone [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxohexanoyl-L-homoserine lactone
-
 ?
2.3.1.184 an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine Aliivibrio fischeri
-
 [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
-
 ?
2.3.1.184 an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine Escherichia coli
-
 [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
-
 ?
2.3.1.184 an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine Serratia marcescens
-
 [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
-
 ?
2.3.1.184 an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine Dickeya chrysanthemi
-
 [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
-
 ?
2.3.1.184 an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine Agrobacterium tumefaciens
-
 [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
-
 ?
2.3.1.184 an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine Serratia sp.
-
 [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
-
 ?
2.3.1.184 an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine Pantoea stewartii
-
 [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
-
 ?
2.3.1.184 an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine Pseudomonas aeruginosa
-
 an [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
-
 ?
2.3.1.184 an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine Yersinia pseudotuberculosis
-
 an [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
-
 ?
2.3.1.184 an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine Pectobacterium carotovorum
-
 an [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
-
 ?
2.3.1.184 an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine Yersinia pestis
-
 an [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
-
 ?
2.3.1.184 an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine Pseudomonas syringae
-
 an [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
-
 ?
2.3.1.184 an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine Yersinia enterocolitica
-
 an [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
-
 ?
2.3.1.184 an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine Serratia sp. 39006
-
 [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
-
 ?
2.3.1.184 an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine Serratia marcescens SS-1
-
 [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
-
 ?
2.3.1.184 butanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine Pseudomonas aeruginosa RhlI [acyl-carrier protein] + S-methyl-5'-thioadenosine + butanoyl-L-homoserine lactone
-
 ?
2.3.1.184 additional information Serratia sp. SmaI synthesizes predominantly butanoyl-HSL and smaller amounts of hexanoyl-HSL ?
-
 ?
2.3.1.184 additional information Serratia sp. 39006 SmaI synthesizes predominantly butanoyl-HSL and smaller amounts of hexanoyl-HSL ?
-
 ?
2.3.1.184 N-butanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine Serratia sp.
-
 [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-butanoyl-L-homoserine lactone
-
 ?
2.3.1.184 N-butanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine Serratia sp. 39006
-
 [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-butanoyl-L-homoserine lactone
-
 ?
2.3.1.184 N-hexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine Serratia sp.
-
 [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-hexanoyl-L-homoserine lactone
-
 ?
2.3.1.184 N-hexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine Serratia sp. 39006
-
 [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-hexanoyl-L-homoserine lactone
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.184 Agrobacterium tumefaciens
-
-
-
2.3.1.184 Aliivibrio fischeri
-
-
-
2.3.1.184 Dickeya chrysanthemi
-
 gene expI
-
2.3.1.184 Escherichia coli
-
-
-
2.3.1.184 Pantoea stewartii
-
 formerly Erwinia stewartii, gene esaI
-
2.3.1.184 Pectobacterium carotovorum
-
 formerly Erwinia carotovora, gene expI
-
2.3.1.184 Pseudomonas aeruginosa
-
-
-
2.3.1.184 Pseudomonas syringae
-
 gene psyI
-
2.3.1.184 Serratia marcescens
-
-
-
2.3.1.184 Serratia marcescens SS-1
-
-
-
2.3.1.184 Serratia sp.
-
 gene smaI
-
2.3.1.184 Serratia sp. 39006
-
 gene smaI
-
2.3.1.184 Yersinia enterocolitica
-
 gene yenI
-
2.3.1.184 Yersinia pestis
-
 gene ypeI
-
2.3.1.184 Yersinia pseudotuberculosis
-
 gene yspI
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.184 3-oxo-octanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
-
 Agrobacterium tumefaciens [acyl-carrier protein] + S-methyl-5'-thioadenosine + 3-oxo-octanoyl-L-homoserine lactone
-
 ?
2.3.1.184 3-oxo-octanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine TraI synthesizes primarily 3-oxo-octanoyl homoserine lactone Agrobacterium tumefaciens [acyl-carrier protein] + S-methyl-5'-thioadenosine + 3-oxo-octanoyl-L-homoserine lactone
-
 ?
2.3.1.184 3-oxododecanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine LasI Pseudomonas aeruginosa [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxododecanoyl-L-homoserine lactone
-
 ?
2.3.1.184 3-oxohexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
-
 Aliivibrio fischeri [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxohexanoyl-L-homoserine lactone
-
 ?
2.3.1.184 3-oxohexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
-
 Serratia marcescens [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxohexanoyl-L-homoserine lactone
-
 ?
2.3.1.184 3-oxohexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
-
 Yersinia pseudotuberculosis [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxohexanoyl-L-homoserine lactone
-
 ?
2.3.1.184 3-oxohexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
-
 Dickeya chrysanthemi [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxohexanoyl-L-homoserine lactone
-
 ?
2.3.1.184 3-oxohexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
-
 Pectobacterium carotovorum [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxohexanoyl-L-homoserine lactone
-
 ?
2.3.1.184 3-oxohexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
-
 Yersinia pestis [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxohexanoyl-L-homoserine lactone
-
 ?
2.3.1.184 3-oxohexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
-
 Pseudomonas syringae [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxohexanoyl-L-homoserine lactone
-
 ?
2.3.1.184 3-oxohexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
-
 Yersinia enterocolitica [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxohexanoyl-L-homoserine lactone
-
 ?
2.3.1.184 3-oxohexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
-
 Pantoea stewartii [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxohexanoyl-L-homoserine lactone
-
 ?
2.3.1.184 3-oxohexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine SpnI (like EsaI) synthesizes primarily N-3-oxohexanoyl-L-homoserine lactone Serratia marcescens [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxohexanoyl-L-homoserine lactone
-
 ?
2.3.1.184 3-oxohexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine PsyI synthesize predominantly N-3-oxohexanoyl-L-homoserine lactone Pseudomonas syringae [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxohexanoyl-L-homoserine lactone
-
 ?
2.3.1.184 3-oxohexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
-
 Serratia marcescens SS-1 [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxohexanoyl-L-homoserine lactone
-
 ?
2.3.1.184 3-oxohexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine SpnI (like EsaI) synthesizes primarily N-3-oxohexanoyl-L-homoserine lactone Serratia marcescens SS-1 [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxohexanoyl-L-homoserine lactone
-
 ?
2.3.1.184 an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine
-
 Aliivibrio fischeri [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
-
 ?
2.3.1.184 an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine
-
 Escherichia coli [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
-
 ?
2.3.1.184 an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine
-
 Serratia marcescens [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
-
 ?
2.3.1.184 an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine
-
 Dickeya chrysanthemi [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
-
 ?
2.3.1.184 an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine
-
 Agrobacterium tumefaciens [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
-
 ?
2.3.1.184 an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine
-
 Serratia sp. [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
-
 ?
2.3.1.184 an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine
-
 Pantoea stewartii [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
-
 ?
2.3.1.184 an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine
-
 Serratia sp. 39006 [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
-
 ?
2.3.1.184 an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine
-
 Serratia marcescens SS-1 [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
-
 ?
2.3.1.184 an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine
-
 Pseudomonas aeruginosa an [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
-
 ?
2.3.1.184 an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine
-
 Yersinia pseudotuberculosis an [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
-
 ?
2.3.1.184 an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine
-
 Pectobacterium carotovorum an [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
-
 ?
2.3.1.184 an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine
-
 Yersinia pestis an [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
-
 ?
2.3.1.184 an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine
-
 Pseudomonas syringae an [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
-
 ?
2.3.1.184 an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine
-
 Yersinia enterocolitica an [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
-
 ?
2.3.1.184 butanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine RhlI Pseudomonas aeruginosa [acyl-carrier protein] + S-methyl-5'-thioadenosine + butanoyl-L-homoserine lactone
-
 ?
2.3.1.184 additional information SmaI synthesizes predominantly butanoyl-HSL and smaller amounts of hexanoyl-HSL Serratia sp. ?
-
 ?
2.3.1.184 additional information SmaI synthesizes predominantly butanoyl-HSL and smaller amounts of hexanoyl-HSL Serratia sp. 39006 ?
-
 ?
2.3.1.184 N-butanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
-
 Serratia sp. [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-butanoyl-L-homoserine lactone
-
 ?
2.3.1.184 N-butanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
-
 Serratia sp. 39006 [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-butanoyl-L-homoserine lactone
-
 ?
2.3.1.184 N-hexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
-
 Serratia sp. [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-hexanoyl-L-homoserine lactone
-
 ?
2.3.1.184 N-hexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
-
 Serratia sp. 39006 [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-hexanoyl-L-homoserine lactone
-
 ?
2.3.1.184 octanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
-
 Escherichia coli [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-octanoyl-L-homoserine lactone
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.184 AHL synthase
-
 Aliivibrio fischeri
2.3.1.184 AHL synthase
-
 Escherichia coli
2.3.1.184 AHL synthase
-
 Pseudomonas aeruginosa
2.3.1.184 AHL synthase
-
 Serratia marcescens
2.3.1.184 AHL synthase
-
 Yersinia pseudotuberculosis
2.3.1.184 AHL synthase
-
 Dickeya chrysanthemi
2.3.1.184 AHL synthase
-
 Pectobacterium carotovorum
2.3.1.184 AHL synthase
-
 Yersinia pestis
2.3.1.184 AHL synthase
-
 Pseudomonas syringae
2.3.1.184 AHL synthase
-
 Agrobacterium tumefaciens
2.3.1.184 AHL synthase
-
 Serratia sp.
2.3.1.184 AHL synthase
-
 Yersinia enterocolitica
2.3.1.184 AHL synthase
-
 Pantoea stewartii
2.3.1.184 EsaI
-
 Pantoea stewartii
2.3.1.184 ExpI
-
 Dickeya chrysanthemi
2.3.1.184 ExpI
-
 Pectobacterium carotovorum
2.3.1.184 LasI
-
 Pseudomonas aeruginosa
2.3.1.184 LuxI
-
 Aliivibrio fischeri
2.3.1.184 PsyI
-
 Pseudomonas syringae
2.3.1.184 RhlI
-
 Pseudomonas aeruginosa
2.3.1.184 SmaI
-
 Serratia sp.
2.3.1.184 SpnI
-
 Serratia marcescens
2.3.1.184 TraI
-
 Agrobacterium tumefaciens
2.3.1.184 YenI
-
 Yersinia enterocolitica
2.3.1.184 YpeRI
-
 Yersinia pestis
2.3.1.184 YspRI
-
 Yersinia pseudotuberculosis

Expression

EC Number Organism Comment Expression
2.3.1.184 Pectobacterium carotovorum ExpR negatively regulates ExpI expression down
2.3.1.184 Dickeya chrysanthemi ExpR1 negatively regulates ExpI expression down

General Information

EC Number General Information Comment Organism
2.3.1.184 evolution ExpI is related to members of the LuxI family Dickeya chrysanthemi
2.3.1.184 evolution ExpI is related to members of the LuxI family Pectobacterium carotovorum
2.3.1.184 malfunction a smaI mutation abolishes the synthesis of the antibiotic carbapenem, the pigment prodigiosin, and several hydrolytic enzymes, while a smaR smaI double mutant restores their production Serratia sp.
2.3.1.184 malfunction an expR-virR-expI triple mutant is a phenocopy of the virR-expI double mutant, suggesting that ExpR does not play any role in regulating these genes. Exoenzyme production in a virR-expI mutant is still induced at high cell density, rather than constitutive Pectobacterium carotovorum
2.3.1.184 malfunction disruption of esaI caused a sharp decrease in exopolysaccharide accumulation, and production was restored by adding N-3-oxohexanoyl-L-homoserine lactone. EsaR mutants overproduce the same exopolysaccharide, indicating that null mutations in esaR and esaI have opposite phenotypes Pantoea stewartii
2.3.1.184 malfunction mutation of expI abolishes production of two N-acyl-L-homoserine lactones, but does not affect the production of a third one, suggesting the existence of at least one more AHL synthase gene. Mutations of expI and expR have little effect on pectate lyase synthesis, which remains quorum-regulated Dickeya chrysanthemi
2.3.1.184 additional information LuxR is an N-3-oxohexanoyl-L-homoserine lactone sensor and an N-3-oxohexanoyl-L-homoserine lactone-dependent transcriptional activator of the luciferase operon. As a population of Vibrio fischeri cells grows in density, the concentration of external N-3-oxohexanoyl-L-homoserine lactone increases. When the concentration of this signal reaches the nanomolar range, its passive efflux from the cells becomes balanced by an influx, so that it can interact with LuxR. LuxR-OHHL complexes bind the promoter of the luxICDABEG operon and activate its transcription. LuxR structure, overview. Three amino acids clustered in the C-terminal domain of LuxR are required for positive control of transcription. Molecular mechanism of action of LuxR as transcription factor, overview Aliivibrio fischeri
2.3.1.184 additional information molecular mechanism of action of EsaR as transcription factor, overview Pantoea stewartii
2.3.1.184 additional information molecular mechanism of action of EsaR-type protein PsyR as transcription factor, overview Pseudomonas syringae
2.3.1.184 additional information molecular mechanism of action of ExpR as transcription factor, overview Dickeya chrysanthemi
2.3.1.184 additional information molecular mechanism of action of ExpR as transcription factor, overview Pectobacterium carotovorum
2.3.1.184 additional information molecular mechanism of action of LuxR-like YpeR as transcription factor, the organism encodes two LuxR/LuxI, e.g. the YpeI/YpeR, systems, overview Yersinia pestis
2.3.1.184 additional information molecular mechanism of action of LuxR-like YspR as transcription factor, the organism encodes two LuxR/LuxI, e.g. the YspI/YspR, systems, overview Yersinia pseudotuberculosis
2.3.1.184 additional information molecular mechanism of action of SmaR as transcription factor, LuxR-type protein SmaR activity is blocked by the cognate N-acyl-L-homoserine lactone, overview Serratia sp.
2.3.1.184 additional information molecular mechanism of action of SpnR as transcription factor, overview. SpnR directly represses target promoters, while the N-acyl-L-homoserine lactone synthesized by SpnI antagonizes SpnR. The spnR/I genes are located on at mobile genetic element, and SpnR represses transcription of the Tn3-type transposase of this element Serratia marcescens
2.3.1.184 additional information molecular mechanism of action of YenR as transcription factor, overview Yersinia enterocolitica
2.3.1.184 additional information the LasR protein of Pseudomonas aeruginosa is a central component of a regulatory web that controls the expression of hundreds of genes, some of which play direct roles in disease, molecular mechanism of action of LasR as transcription factor, it detects 3-oxododecanoyl-L-homoserine lactone, overview. The so-called orphan receptor QscR, which also detects 3-oxododecanoyl-L-homoserine lactone. The second quorum sensing receptor, RhlR, detects butanoyl-L-homoserine lactone and interacts with its cognate AHL synthase, RhlI. Unlike LuxR, LasR does not detectably release its N-acyl-homoserine lactone. It binds to six LasR-dependent promoters Pseudomonas aeruginosa
2.3.1.184 physiological function chemical communication within populations of bacteria enable them to estimate their population density, a process sometimes referred to as quorum sensing. Signalling among Proteobacteria often involves N-acyl-homoserine lactones, which have identical polar head groups and a variety of hydrophobic acyl groups that differ in length, oxidation, and desaturation. AHL signal molecules are often referred to as autoinducers. They are synthesized by LuxI-type AHL synthases. Most LuxR-type receptors, i.e. LuxR, LasR, and TraR, and SpnR in Serratia marcescens require N-acyl-homoserine lactones for function and in at least some cases, N-acyl-homoserine lactones are required for protein folding and protease resistance. The SpnI/SpnR system controls production of prodigiosin, endonuclease, and a surfactant that affects motility Serratia marcescens
2.3.1.184 physiological function chemical communication within populations of bacteria enable them to estimate their population density, a process sometimes referred to as quorum sensing. Signalling among Proteobacteria often involves N-acyl-homoserine lactones, which have identical polar head groups and a variety of hydrophobic acyl groups that differ in length, oxidation, and desaturation. AHL signal molecules are often referred to as autoinducers. They are synthesized by LuxI-type AHL synthases. Most LuxR-type receptors, i.e. LuxR, LasR, and TraR, and YenR in Yersinia enterocolitica require N-acyl-homoserine lactones for function and in at least some cases, N-acyl-homoserine lactones are required for protein folding and protease resistance Yersinia enterocolitica
2.3.1.184 physiological function chemical communication within populations of bacteria enable them to estimate their population density, a process sometimes referred to as quorum sensing. Signalling among Proteobacteria often involves N-acyl-homoserine lactones, which have identical polar head groups and a variety of hydrophobic acyl groups that differ in length, oxidation, and desaturation. AHL signal molecules are often referred to as autoinducers. They are synthesized by LuxI-type AHL synthases. Most LuxR-type receptors, i.e. LuxR, LasR, and TraR, EsaR in Pantoea stewartii require N-acyl-homoserine lactones for function and in at least some cases, N-acyl-homoserine lactones are required for protein folding and protease resistance. EsaR represses transcription of its own gene, but does not affect expression of esaI. Nevertheless EsaR does regulate EPS and is antagonized by N-3-oxohexanoyl-L-homoserine lactone Pantoea stewartii
2.3.1.184 physiological function chemical communication within populations of bacteria enable them to estimate their population density, a process sometimes referred to as quorum sensing. Signalling among Proteobacteria often involves N-acyl-homoserine lactones, which have identical polar head groups and a variety of hydrophobic acyl groups that differ in length, oxidation, and desaturation. AHL signal molecules are often referred to as autoinducers. They are synthesized by LuxI-type AHL synthases. Most LuxR-type receptors, i.e. LuxR, LasR, and TraR, or SdiA in Escherichia coli require N-acyl-homoserine lactones for function and in at least some cases, N-acyl-homoserine lactones are required for protein folding and protease resistance, SdiA binds N-octanoyl-L-homoserine lactone enhancing its solubility during protein synthesis Escherichia coli
2.3.1.184 physiological function chemical communication within populations of bacteria enable them to estimate their population density, a process sometimes referred to as quorum sensing. Signalling among Proteobacteria often involves N-acyl-homoserine lactones, which have identical polar head groups and a variety of hydrophobic acyl groups that differ in length, oxidation, and desaturation. AHL signal molecules are often referred to as autoinducers. They are synthesized by LuxI-type AHL synthases. Most LuxR-type receptors, i.e. LuxR, LasR, and TraR, require N-acyl-homoserine lactones for function and in at least some cases, N-acyl-homoserine lactones are required for protein folding and protease resistance Aliivibrio fischeri
2.3.1.184 physiological function chemical communication within populations of bacteria enable them to estimate their population density, a process sometimes referred to as quorum sensing. Signalling among Proteobacteria often involves N-acyl-homoserine lactones, which have identical polar head groups and a variety of hydrophobic acyl groups that differ in length, oxidation, and desaturation. AHL signal molecules are often referred to as autoinducers. They are synthesized by LuxI-type AHL synthases. Most LuxR-type receptors, i.e. LuxR, LasR, and TraR, require N-acyl-homoserine lactones for function and in at least some cases, N-acyl-homoserine lactones are required for protein folding and protease resistance Yersinia pseudotuberculosis
2.3.1.184 physiological function chemical communication within populations of bacteria enable them to estimate their population density, a process sometimes referred to as quorum sensing. Signalling among Proteobacteria often involves N-acyl-homoserine lactones, which have identical polar head groups and a variety of hydrophobic acyl groups that differ in length, oxidation, and desaturation. AHL signal molecules are often referred to as autoinducers. They are synthesized by LuxI-type AHL synthases. Most LuxR-type receptors, i.e. LuxR, LasR, and TraR, require N-acyl-homoserine lactones for function and in at least some cases, N-acyl-homoserine lactones are required for protein folding and protease resistance Yersinia pestis
2.3.1.184 physiological function chemical communication within populations of bacteria enable them to estimate their population density, a process sometimes referred to as quorum sensing. Signalling among Proteobacteria often involves N-acyl-homoserine lactones, which have identical polar head groups and a variety of hydrophobic acyl groups that differ in length, oxidation, and desaturation. AHL signal molecules are often referred to as autoinducers. They are synthesized by LuxI-type AHL synthases. Most LuxR-type receptors, i.e. LuxR, LasR, and TraR, require N-acyl-homoserine lactones for function and in at least some cases, N-acyl-homoserine lactones are required for protein folding and protease resistance Pseudomonas syringae
2.3.1.184 physiological function chemical communication within populations of bacteria enable them to estimate their population density, a process sometimes referred to as quorum sensing. Signalling among Proteobacteria often involves N-acyl-homoserine lactones, which have identical polar head groups and a variety of hydrophobic acyl groups that differ in length, oxidation, and desaturation. AHL signal molecules are often referred to as autoinducers. They are synthesized by LuxI-type AHL synthases. Most LuxR-type receptors, i.e. LuxR, LasR, and TraR, require N-acyl-homoserine lactones for function and in at least some cases, N-acyl-homoserine lactones are required for protein folding and protease resistance. The LasR/LasI system stimulates production of the RhlI/RhlR system, causing the two Pseudomonas aeruginosa quorum-sensing circuits to initiate sequentially Pseudomonas aeruginosa
2.3.1.184 physiological function chemical communication within populations of bacteria enable them to estimate their population density, a process sometimes referred to as quorum sensing. Signalling among Proteobacteria often involves N-acyl-homoserine lactones, which have identical polar head groups and a variety of hydrophobic acyl groups that differ in length, oxidation, and desaturation. AHL signal molecules are often referred to as autoinducers. They are synthesized by LuxI-type AHL synthases. Most LuxR-type receptors, i.e. LuxR, LasR, and TraR, require N-acyl-homoserine lactones for function and in at least some cases, N-acyl-homoserine lactones are required for protein folding and protease resistance. TraR is an 3-oxo-octanoyl-L-homoserine lactone-dependent activator of genes required for vegetative replication and conjugative transfer of the Ti plasmid, TraR binds these sites as a dimer and without cooperativity, structure, overview Agrobacterium tumefaciens
2.3.1.184 physiological function chemical communication within populations of bacteria enable them to estimate their population density, a process sometimes referred to as quorum sensing. Signalling among Proteobacteria often involves N-acyl-homoserine lactones, which have identical polar head groups and a variety of hydrophobic acyl groups that differ in length, oxidation, and desaturation. AHL signal molecules are often referred to as autoinducers. They are synthesized by LuxI-type AHL synthases. Most LuxR-type receptors, i.e. LuxR, LasR, and TraR, require N-acyl-homoserine lactones for function and in at least some cases, N-acyl-homoserine lactones are required for protein folding and protease resistanceCarR is also a LuxR homolog and directly activates the car operon. CarR is rather closely related to members of the EsaR family, which might suggest that its activity can be blocked by cognate N-acyl-L-homoserine lactones. CarR is often referred to as N-acyl-L-homoserine lactone-independent, as it was able to activate the car operon of Pectobacterium carotovorum in a strain lacking N-acyl-L-homoserine lactones. CarR is essential for transcription of the Serratia car operon and functions perfectly well in an N-acyl-L-homoserine lactone-defective strain. It still seems possible that CarR could be antagonized by N-acyl-L-homoserine lactones, although it functions in strains that produce N-butanoyl-L-homoserine lactone Serratia sp.
2.3.1.184 physiological function ExpI controls the expression of the corresponding genes encoding enzymes capable of degrading pectate, cellulose, and protein involved in maceration of plant tissues of the pathogen's host plants. Chemical communication within populations of bacteria enable them to estimate their population density, a process sometimes referred to as quorum sensing. Signalling among Proteobacteria often involves N-acyl-homoserine lactones, which have identical polar head groups and a variety of hydrophobic acyl groups that differ in length, oxidation, and desaturation. AHL signal molecules are often referred to as autoinducers. They are synthesized by LuxI-type AHL synthases. Most LuxR-type receptors, i.e. LuxR, LasR, and TraR, and ExpR1 and ExpR2 (or VirR) in Pectobacterium carotovorum, require N-acyl-homoserine lactones for function and in at least some cases, N-acyl-homoserine lactones are required for protein folding and protease resistance. Receptor ExpR2 or VirR, detects a broader variety of N-acyl-homoserine lactones than ExpR1, and VirR is solely responsible for exoenzyme production. CarR is also a LuxR homolog and directly activates the car operon. CarR is rather closely related to members of the EsaR family, which might suggest that its activity can be blocked by cognate N-acyl-L-homoserine lactones. CarR is often referred to as N-acyl-L-homoserine lactone-independent, as it was able to activate the car operon of Pectobacterium carotovorum in a strain lacking N-acyl-L-homoserine lactones. The CarR protein of Pectobacterium carotovorum requires N-3-oxohexanoyl-L-homoserine lactone synthesized by ExpI to activate the organism's car operon Pectobacterium carotovorum
2.3.1.184 physiological function ExpI controls the expression of the corresponding genes encoding enzymes capable of degrading pectate, cellulose, and protein involved in maceration of plant tissues of the pathogen's host plants. Chemical communication within populations of bacteria enable them to estimate their population density, a process sometimes referred to as quorum sensing. Signalling among Proteobacteria often involves N-acyl-homoserine lactones, which have identical polar head groups and a variety of hydrophobic acyl groups that differ in length, oxidation, and desaturation. AHL signal molecules are often referred to as autoinducers. They are synthesized by LuxI-type AHL synthases. Most LuxR-type receptors, i.e. LuxR, LasR, and TraR, require N-acyl-homoserine lactones for function and in at least some cases, N-acyl-homoserine lactones are required for protein folding and protease resistance. Apo-ExpR autorepresses its synthesis, while N-3-oxohexanoyl-L-homoserine lactone almost fully blocked autorepression Dickeya chrysanthemi