Literature summary extracted from

Rubio, A.; Moore, J.; Varoglu, M.; Conrad, M.; Chu, M.; Shaw, W.; Silverman, J.A.
LC-MS/MS characterization of phospholipid content in daptomycin-susceptible and -resistant isolates of Staphylococcus aureus with mutations in mprF (2012), Mol. Membr. Biol., 29, 1-8.

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
2.3.2.3	membrane	an integral membrane protein	Staphylococcus aureus	16020	-

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.3.2.3	Staphylococcus aureus	-	-	-

Synonyms

EC Number	Synonyms	Comment	Organism
2.3.2.3	MprF	a membrane protein with both lysylphosphatidylglycerol synthase and flippase activities	Staphylococcus aureus

General Information

EC Number	General Information	Comment	Organism
2.3.2.3	malfunction	a MprF knockout mutant demonstrates a substantial increase in the phosphatidylglycerol:lysylphosphatidylglycerol ratio of the membrane	Staphylococcus aureus
2.3.2.3	metabolism	the C-terminal domain of the enzyme is responsible for the synthesis of lysylphosphatidylglycerol	Staphylococcus aureus
2.3.2.3	physiological function	the mprFgene confers daptomycin resistance	Staphylococcus aureus

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Release 2023.1 (January 2023)