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Literature summary extracted from

  • Andrade, C.; Wink, M.; Margis, R.; Borojevic, R.; Battastini, A.; Guma, F.
    Changes in E-NTPDase 3 expression and extracellular nucleotide hydrolysis during the myofibroblast/lipocyte differentiation (2010), Mol. Cell. Biochem., 339, 79-87.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.6.1.5 genes Entpd1, 2, 3, 5, 6, and Entpd8 Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.6.1.5 extracellular
-
 Mus musculus
-
-
3.6.1.5 membrane
-
 Mus musculus 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.6.1.5 Ca2+ required Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.6.1.5 ADP + H2O Mus musculus
-
 AMP + phosphate
-
 ?
3.6.1.5 ATP + 2 H2O Mus musculus best substrate in hepatic stellate cells AMP + 2 phosphate
-
 ?
3.6.1.5 CDP + H2O Mus musculus
-
 CMP + phosphate
-
 ?
3.6.1.5 CTP + 2 H2O Mus musculus
-
 CMP + 2 phosphate
-
 ?
3.6.1.5 GTP + 2 H2O Mus musculus
-
 GMP + 2 phosphate
-
 ?
3.6.1.5 additional information Mus musculus substrate specificity in myofibroblasts and quiescent-like hepatic stellate cells, overview ?
-
 ?
3.6.1.5 UDP + H2O Mus musculus best substrate in myofibroblasts UMP + phosphate
-
 ?
3.6.1.5 UTP + 2 H2O Mus musculus
-
 UMP + 2 phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.6.1.5 Mus musculus
-
 genes Entpd1, 2, 3, 5, 6, and Entpd8
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.6.1.5 GRX cell hepatic stellate cell line. Both phenotypes of GRX cell line express NTPDase 3 and 5, but only activated cells express NTPDase 6, quantitative real-time PCR expression analysis of Entpd genes, overview Mus musculus
-
3.6.1.5 hepatic stellate cell
-
 Mus musculus
-
3.6.1.5 liver
-
 Mus musculus
-
3.6.1.5 additional information NTPs may be hydrolyzed mainly by NTPDase 3 in GRX cells and the increase in the NTPs hydrolysis observed in lipocytes is probably related to the up-regulation of Entpd3 mRNA expression Mus musculus
-
3.6.1.5 myofibroblast
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.1.5 ADP + H2O
-
 Mus musculus AMP + phosphate
-
 ?
3.6.1.5 ATP + 2 H2O
-
 Mus musculus AMP + 2 phosphate
-
 ?
3.6.1.5 ATP + 2 H2O best substrate in hepatic stellate cells Mus musculus AMP + 2 phosphate
-
 ?
3.6.1.5 CDP + H2O
-
 Mus musculus CMP + phosphate
-
 ?
3.6.1.5 CTP + 2 H2O
-
 Mus musculus CMP + 2 phosphate
-
 ?
3.6.1.5 GTP + 2 H2O
-
 Mus musculus GMP + 2 phosphate
-
 ?
3.6.1.5 additional information substrate specificity in myofibroblasts and quiescent-like hepatic stellate cells, overview Mus musculus ?
-
 ?
3.6.1.5 UDP + H2O
-
 Mus musculus UMP + phosphate
-
 ?
3.6.1.5 UDP + H2O best substrate in myofibroblasts Mus musculus UMP + phosphate
-
 ?
3.6.1.5 UTP + 2 H2O
-
 Mus musculus UMP + 2 phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.6.1.5 E-NTPDase 3
-
 Mus musculus
3.6.1.5 ecto-nucleoside triphosphate diphosphohydrolase
-
 Mus musculus
3.6.1.5 NTPDase 3
-
 Mus musculus
3.6.1.5 NTPDase 5
-
 Mus musculus
3.6.1.5 NTPDase 6
-
 Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.6.1.5 37
-
 assay at Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.6.1.5 7.4
-
 assay at Mus musculus

General Information

EC Number General Information Comment Organism
3.6.1.5 evolution the enzyme is a member of the E-NTPDase family Mus musculus
3.6.1.5 physiological function ecto-nucleoside triphosphate diphosphohydrolases, E-NTPDases, regulate the concentration of extracellular nucleotides, signaling molecules that play a role in the pathogenesis of hepatic fibrosis. Up-regulation of Entpd3 mRNA expression modulates the extracellular concentration of nucleotides/nucleosides and affect P2-receptor signaling differently in quiescent-like cells and may play a role in the regulation of hepatic stellate cell functions Mus musculus