Literature summary extracted from

Singh, N.; Lorbeck, M.T.; Zervos, A.; Zimmerman, J.; Elefant, F.
The histone acetyltransferase Elp3 plays in active role in the control of synaptic bouton expansion and sleep in Drosophila (2010), J. Neurochem., 115, 493-504.

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.3.1.48	Drosophila melanogaster	Q9VQZ6	-	-

Synonyms

EC Number	Synonyms	Comment	Organism
2.3.1.48	elongator protein 3	catalytic subunit of the elongator complex	Drosophila melanogaster
2.3.1.48	ELP3	-	Drosophila melanogaster

General Information

EC Number	General Information	Comment	Organism
2.3.1.48	physiological function	targeted reduction of ELP3 specifically in the developing Drosophila nervous system leads to a hyperactive phenotype with increase in climbing and locomotor activities and sleep loss in the adult flies, a significant expansion in synaptic bouton number and axonal length and branching in the larval neuromuscular junction as well as the misregulation of genes involved in sleep, vesicle transport and fusion, and protein chaperone activity. Ubiquitous reduction of ELP3 results in lethality	Drosophila melanogaster

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)