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Literature summary extracted from

  • Gahoi, S.; Mandal, R.S.; Ivanisenko, N.; Shrivastava, P.; Jain, S.; Singh, A.K.; Raghunandanan, M.V.; Kanchan, S.; Taneja, B.; Mandal, C.; Ivanisenko, V.A.; Kumar, A.; Kumar, R.; Open Source Drug Discovery Consortium; Ramachandran, S.
    Computational screening for new inhibitors of M. tuberculosis mycolyltransferases antigen 85 group of proteins as potential drug targets (2012), J. Biomol. Struct. Dyn., 1, 30-43.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.3.1.122 drug development antigen 85 proteins are potential drug targets Mycobacterium tuberculosis

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.122 ethyl 3-phenoxybenzyl butylphosphonate
-
 Mycobacterium tuberculosis
2.3.1.122 additional information inhibitor screening by molecular docking, overview Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.122 2 alpha,alpha-trehalose 6-mycolate Mycobacterium tuberculosis
-
 alpha,alpha-trehalose + alpha,alpha-trehalose 6,6'-bismycolate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.122 Mycobacterium tuberculosis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.122 2 alpha,alpha-trehalose 6-mycolate
-
 Mycobacterium tuberculosis alpha,alpha-trehalose + alpha,alpha-trehalose 6,6'-bismycolate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.122 antigen 85C
-
 Mycobacterium tuberculosis
2.3.1.122 mycolyltransferase
-
 Mycobacterium tuberculosis

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.3.1.122 0.002
-
 pH and temperature not specified in the publication Mycobacterium tuberculosis ethyl 3-phenoxybenzyl butylphosphonate

General Information

EC Number General Information Comment Organism
2.3.1.122 physiological function the enzyme is responsible for converting trehalose monomycolate to trehalose dimycolate, which contributes to cell wall stability Mycobacterium tuberculosis