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Literature summary extracted from

  • Belanova, M.; Dianiskova, P.; Brennan, P.J.; Completo, G.C.; Rose, N.L.; Lowary, T.L.; Mikusova, K.
    Galactosyl transferases in mycobacterial cell wall synthesis (2008), J. Bacteriol., 190, 1141-1145.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.287 expressed in Escherichia coli BL21(DE3) cells Mycolicibacterium smegmatis
2.4.1.288 expressed in Escherichia coli BL21(DE3) cells Mycolicibacterium smegmatis

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.287 Mycolicibacterium smegmatis
-
-
-
2.4.1.288 Mycolicibacterium smegmatis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.287 additional information the enzyme harbors dual beta-(1->4) and beta-(1->5) galactofuranose transferase activities. The enzyme cannot catalyze subsequent galactan chain extension. Gal-Gal-Gal-Rha-GlcNAc-P-P-decaprenol is not a substrate Mycolicibacterium smegmatis ?
-
 ?
2.4.1.287 UDP-alpha-D-galactofuranose + alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol
-
 Mycolicibacterium smegmatis UDP + beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol
-
 ?
2.4.1.288 additional information octyl alpha-L-rhamnopyranosyl-(1->3)-2-acetamido-2-deoxy-alpha-D-glucopyranoside and octyl alpha-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-2-acetamido-2-deoxy-alpha-D-glucopyranoside are no effective substrates Mycolicibacterium smegmatis ?
-
 ?
2.4.1.288 UDP-alpha-D-galactofuranose + beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol
-
 Mycolicibacterium smegmatis UDP + [beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->6)]14-beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol
-
 ?
2.4.1.288 UDP-alpha-D-galactofuranose + octyl beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-2-acetamido-2-deoxy-alpha-D-glucopyranoside
-
 Mycolicibacterium smegmatis UDP + octyl beta-D-galactofuranosyl-(1->6)-beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-2-acetamido-2-deoxy-alpha-D-glucopyranoside
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.287 galactofuranosyl transferase 1
-
 Mycolicibacterium smegmatis
2.4.1.287 GlfT1
-
 Mycolicibacterium smegmatis
2.4.1.288 galactofuranosyl transferase 2
-
 Mycolicibacterium smegmatis
2.4.1.288 GlfT2
-
 Mycolicibacterium smegmatis
2.4.1.288 Rv3808c
-
 Mycolicibacterium smegmatis

General Information

EC Number General Information Comment Organism
2.4.1.287 metabolism the enzyme is involved in the initial steps of galactan formation gand initiates galactan synthesis on the C50-P-P-GlcNAc-Rha acceptor Mycolicibacterium smegmatis
2.4.1.288 metabolism the enzyme catalyzes the addition of the third and subsequent Galf residues, but not the first two, to the lipid template in galactan synthesis Mycolicibacterium smegmatis