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Literature summary extracted from

  • Krauke, Y.; Sychrova, H.
    Cnh1 Na+ /H+ antiporter and Ena1 Na+-ATPase play different roles in cation homeostasis and cell physiology of Candida glabrata (2011), FEMS Yeast Res., 11, 29-41.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
7.2.2.3 expressed in Saccharomyces cerevisiae strain w303-1a Nakaseomyces glabratus

Organism

EC Number Organism UniProt Comment Textmining
7.2.2.3 Nakaseomyces glabratus P13587
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-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.2.2.3 ATP + H2O + Na+/in
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 Nakaseomyces glabratus ADP + phosphate + Na+/out
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 ?
7.2.2.3 additional information the enzyme has broad substrate specificity for alkali metal cations and is able to transport both sodium and potassium when expressed in Saccharomyces cerevisiae Nakaseomyces glabratus ?
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 ?

Synonyms

EC Number Synonyms Comment Organism
7.2.2.3 Ena1
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 Nakaseomyces glabratus
7.2.2.3 Na+-ATPase
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 Nakaseomyces glabratus

Expression

EC Number Organism Comment Expression
7.2.2.3 Nakaseomyces glabratus the Ena1 Na+-ATPase gene is highly upregulated by an increased osmotic pressure or sodium concentration (25fold increase of expression during the first 60 min of exposure to 1000 mM NaCl and then expression partly drops (12fold higher expression after 90 min)) up

General Information

EC Number General Information Comment Organism
7.2.2.3 malfunction deletion of ENA1 has no effect on the tolerance to potassium and rubidium. Mutant cells are unable to grow on media containing higher concentrations of sodium and lithium cations Nakaseomyces glabratus
7.2.2.3 physiological function Na+ATPase is involved in Candida glabrata tolerance to high concentrations of Na+ and Li+ Nakaseomyces glabratus