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Literature summary extracted from

  • Geissler, S.; Zwarg, M.; Knütter, I.; Markwardt, F.; Brandsch, M.
    The bioactive dipeptide anserine is transported by human proton-coupled peptide transporters (2010), FEBS J., 277, 790-795.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
7.4.2.5 expression in Caco-2 cells and HeLa cells Homo sapiens
7.4.2.5 expression in spontaneous hypertensive rat kidney proximal tubule cells Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.4.2.5 anserine inhibits uptake of glycylsarcosine Homo sapiens
7.4.2.5 anserine inhibits uptake of glycylsarcosine Rattus norvegicus
7.4.2.5 carnosine inhibits uptake of glycylsarcosine Homo sapiens
7.4.2.5 carnosine inhibits uptake of glycylsarcosine Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
7.4.2.5 Homo sapiens
-
-
-
7.4.2.5 Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.4.2.5 ATP + H2O + anserine/out
-
 Homo sapiens ADP + phosphate + anserine/in
-
 ?
7.4.2.5 ATP + H2O + carnosine/out
-
 Homo sapiens ADP + phosphate + carnosine/in
-
 ?
7.4.2.5 ATP + H2O + glycylsarcosine/out
-
 Homo sapiens ADP + phosphate + glycylsarcosine/in
-
 ?
7.4.2.5 additional information using the two-electrode, voltage-clamp technique at Xenopus laevis oocytes, strong hPEPT1-specific inward transport currents are recorded for glycylsarcosine, anserine and carnosine, but not for glycine Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.4.2.5 H+/peptide cotransporter
-
 Homo sapiens
7.4.2.5 H+/peptide cotransporter
-
 Rattus norvegicus
7.4.2.5 PepT1
-
 Homo sapiens
7.4.2.5 PEPT2
-
 Rattus norvegicus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
7.4.2.5 0.033
-
 anserine pH 6.0, 22°C Rattus norvegicus
7.4.2.5 0.65
-
 anserine pH 6.0, 22°C, transfection of HeLa cells Homo sapiens
7.4.2.5 1.55
-
 anserine pH 6.0, 22°C, transfection of Caco-2 cells Homo sapiens