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Literature summary extracted from

  • Shaik, K.S.; Meyer, F.; Vazquez, A.V.; Floetenmeyer, M.; Cerdan, M.E.; Moussian, B.
    Sigma-Aminolevulinate synthase is required for apical transcellular barrier formation in the skin of the Drosophila larva (2012), Eur. J. Cell Biol., 91, 204-215.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.37 mitochondrion
-
 Drosophila melanogaster 5739
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Organism

EC Number Organism UniProt Comment Textmining
2.3.1.37 Drosophila melanogaster
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.37 larva
-
 Drosophila melanogaster
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Subunits

EC Number Subunits Comment Organism
2.3.1.37 homodimer
-
 Drosophila melanogaster

Synonyms

EC Number Synonyms Comment Organism
2.3.1.37 ALAS
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 Drosophila melanogaster
2.3.1.37 sigma-aminolevulinate synthase
-
 Drosophila melanogaster

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.37 pyridoxal 5'-phosphate
-
 Drosophila melanogaster

General Information

EC Number General Information Comment Organism
2.3.1.37 malfunction mutation in Alas gena cause massive water loss. The cuticle of alas mutant larvae detaches from the epidermis and its basal region is frayed. Reduction of Alas function results in weakening of the extracellular dityrosines network in the cuticle. Alas activity, which initiates heme biosynthesis in the mitochondrion, might be needed for the formation of a dityrosine-based barrier that confers resistance to the internal hydrostatic pressure protecting both the cuticle from transcellular infiltration of body fluid and the animal from dehydration Drosophila melanogaster