EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
2.1.1.356 | additional information | the E(z)Trm mutation increases the histone H3 (K27) trimethylation efficiency of catalytic subunit E(Z) of Polycomb Repressive Complex 2 | Drosophila melanogaster |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.1.1.356 | Drosophila melanogaster | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.1.1.356 | embryo | - |
Drosophila melanogaster | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.356 | S-adenosyl-L-methionine + histone H3(K27) | Drosophila Polycomb Repressive Complex 2 is a lysine methyltransferase that trimethylates histone H3 (K27) | Drosophila melanogaster | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.1.1.356 | Polycomb repressive complex 2 | - |
Drosophila melanogaster |
2.1.1.356 | PRC2 | - |
Drosophila melanogaster |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.1.1.356 | malfunction | mutations in the catalytic subunit E(Z) that abolish methyltransferase activity disrupt Polycomb silencing, causing derepression of Polycomb target genes in cells where they are normally silenced. Increased histone H3(K27) trimethylation activity of mutant E(Z)Trm causes the premature accumulation of trimethylated histone H3(K27) in early embryogenesis, predestining initially active Polycomb target genes to silencing once Polycomb silencing is initiated | Drosophila melanogaster |