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Literature summary extracted from
- A general acid-general base reaction mechanism for human brain aspartoacylase: A QM/MM study (2012), Comput. Theoret. Chem., 980, 85-91.
No PubMed abstract available
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 3.5.1.15 | R63N | the mutation results in undetectable activity | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.5.1.15 | methylphosphonamidate | - |
Homo sapiens |  |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.5.1.15 | Zn2+ | the enzyme binds one zinc ion per monomer | Homo sapiens | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.5.1.15 | Homo sapiens | P45381 | - |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.5.1.15 | brain | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.5.1.15 | N-acetyl-L-aspartate + H2O | - |
Homo sapiens | L-aspartate + acetate | - |
ir | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.5.1.15 | ASPA | - |
Homo sapiens |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 3.5.1.15 | malfunction | the defect of aspartoacylase is the cause of Canavan disease | Homo sapiens |
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Release 2023.1 (January 2023)
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