EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
7.2.2.21 | HCO3- | cellular Cd2+ uptake increases in the presence of HCO3- | Oncorhynchus mykiss |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
7.2.2.21 | Fe2+ | inhibits cellular Cd2+ uptake through a competitive interaction | Oncorhynchus mykiss | |
7.2.2.21 | additional information | pre-exposure to either 0.01 or 0.1 mM orthovanadate does not affect the cellular Cd2+ uptake rate. After 60 min efflux, approximately 40% and 20% of accumulated Cd2+ in the enterocytes is lost in the absence and presence of orthovanadate, respectively, when compared to 0 min. Pre-exposure to verapamil or lanthanum does not exhibit any effects on the cellular Cd2+ uptake rate | Oncorhynchus mykiss | |
7.2.2.21 | Zn2+ | inhibits cellular Cd2+ uptake through a competitive interaction | Oncorhynchus mykiss |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
7.2.2.21 | 0.00086 | - |
Cd2+/out | pH and temperature not specified in the publication | Oncorhynchus mykiss | |
7.2.2.21 | 0.00169 | - |
Cd2+/out | in the presence of 2.5 mM Fe2+, pH and temperature not specified in the publication | Oncorhynchus mykiss | |
7.2.2.21 | 0.00193 | - |
Cd2+/out | in the presence of 0.01 mM Zn2+, pH and temperature not specified in the publication | Oncorhynchus mykiss |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
7.2.2.21 | additional information | Cd2+ uptake is unaffected by Ca2+ | Oncorhynchus mykiss |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
7.2.2.21 | Oncorhynchus mykiss | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
7.2.2.21 | enterocyte | - |
Oncorhynchus mykiss | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
7.2.2.21 | ATP + H2O + Cd2+/out | - |
Oncorhynchus mykiss | ADP + phosphate + Cd2+/in | - |
? |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
7.2.2.21 | 0.0098 | - |
pH and temperature not specified in the publication | Oncorhynchus mykiss | Zn2+ | |
7.2.2.21 | 2.5 | - |
pH and temperature not specified in the publication | Oncorhynchus mykiss | Fe2+ |