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Literature summary extracted from

  • Jarmula, A.; Fraczyk, T.; Cieplak, P.; Rode, W.
    Mechanism of influence of phosphorylation on serine 124 on a decrease of catalytic activity of human thymidylate synthase (2010), Bioorg. Med. Chem., 18, 3361-3370.
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.45 Homo sapiens
-
-
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Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.1.1.45 phosphoprotein phosphorylation of serine 124 in human thymidylate synthase lowers the catalytic activity of the enzyme. The phosphorylation changes the collective motions of the enzyme, consisting of the suppression of motions especially in the regions flanking the entrance to the active site Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.45 5,10-methylenetetrahydrofolate + dUMP
-
 Homo sapiens dihydrofolate + dTMP
-
 ?